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Title: PALS-14 promotes resistance to Nematocida parisii infection in Caenorhabditis elegans
Microsporidia are common natural pathogens of the nematode Caenorhabditis elegans. Infection of C. elegans by the microsporidian species Nematocida parisii leads to induction of the Intracellular Pathogen Response (IPR), including transcriptional upregulation of 26 pals genes. The divergent ‘pals' sequence signature is conserved with humans, but PALS proteins have unknown biochemical functions. So far, none of the 26 induced pals genes have a demonstrated role in immunity. Here, we use RNAseq data, RNA interference, and CRISPR/Cas9 mutant analysis to identify the N. parisii-induced pals-14 gene as an immune gene that provides defense against microsporidia infection in C. elegans.  more » « less
Award ID(s):
2301657
PAR ID:
10557722
Author(s) / Creator(s):
; ; ;
Publisher / Repository:
microPublication Biology
Date Published:
Journal Name:
MicroPublication
Volume:
2024
ISSN:
2578-9430
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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