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  • Differentially expressed microRNAs in brains of adult females may regulate the maternal block of diapause in Sarcophaga bullata
Title: Differentially expressed microRNAs in brains of adult females may regulate the maternal block of diapause in Sarcophaga bullata
The maternal regulation of diapause is one type of phenotypic plasticity where the experience of the mother leads to changes in the phenotype of her offspring that impact how well-suited they will be to their future environment. Sarcophaga bullata females with a diapause history produce offspring that cannot enter diapause even if they are reared in a diapause inducing environment. Accumulating evidence suggests that microRNAs regulate diapause and, possibly, maternal regulation of diapause. We found significant differences in the abundances of several microRNAs (miR-125–5p, miR-124–3p, miR-31–5p, and miR-277–3p) in brains dissected from adult female S. bullata that had experienced diapause compared to females with no diapause history. We also found moderate differences in the mRNA expression of the circadian-clock related genes, clock, clockwork orange, and period. MiR-124–3p and miR-31–5p are part of a gene network that includes these circadian clock-related genes. Taken together our results suggest the maternal block of diapause in S. bullata is regulated, at least in part, by a network that includes microRNAs and the circadian clock.  more » « less
Award ID(s):
1755318
PAR ID:
10560597
Author(s) / Creator(s):
;
Publisher / Repository:
Elsevier
Date Published:
Journal Name:
Current Research in Insect Science
Volume:
6
Issue:
C
ISSN:
2666-5158
Page Range / eLocation ID:
100099
Subject(s) / Keyword(s):
Insects Epigenetics Anticipatory transgenerational effects Dormancy Circadian clock Seasonal response
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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