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This content will become publicly available on August 28, 2025

Title: Evolution and strain diversity advance exploration of Candida albicans biology
ABSTRACT Fungi were some of the earliest organismal systems used to explore mutational processes and its phenotypic consequences on members of a species. Yeasts that cause significant human disease were quickly incorporated into these investigations to define the genetic and phenotypic drivers of virulence. AmongCandidaspecies,Candida albicanshas emerged as a model for studying genomic processes of evolution because of its clinical relevance, relatively small genome, and ability to tolerate complex chromosomal changes. Here, we describe major recent findings that used evolution of strains from defined genetic backgrounds to delineate mutational and adaptative processes and include how nascent exploration into naturally occurring variation is contributing to these conceptual frameworks. Ultimately, efforts to discern adaptive mechanisms used byC. albicanswill continue to divulge new biology and can better inform treatment regimens for the increasing prevalence of fungal disease.  more » « less
Award ID(s):
2409549
PAR ID:
10565946
Author(s) / Creator(s):
;
Editor(s):
Mitchell, Aaron P
Publisher / Repository:
American Society for Microbiology
Date Published:
Journal Name:
mSphere
Volume:
9
Issue:
8
ISSN:
2379-5042
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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