PurposeTo determineR2and transverse relaxation rates in healthy lung parenchyma at 0.55 T. This is important in that it informs the design and optimization of new imaging methods for 0.55T lung MRI. MethodsExperiments were performed in 3 healthy adult volunteers on a prototype whole‐body 0.55T MRI, using a custom free‐breathing electrocardiogram‐triggered, single‐slice echo‐shifted multi‐echo spin echo (ES‐MCSE) pulse sequence with respiratory navigation. Transverse relaxation ratesR2and and off‐resonance ∆fwere jointly estimated using nonlinear least‐squares estimation. These measurements were compared againstR2estimates from T2‐prepared balanced SSFP (T2‐Prep bSSFP) and estimates from multi‐echo gradient echo, which are used widely but prone to error due to different subvoxel weighting. ResultsThe meanR2and values of lung parenchyma obtained from ES‐MCSE were 17.3 ± 0.7 Hz and 127.5 ± 16.4 Hz (T2 = 61.6 ± 1.7 ms; = 9.5 ms ± 1.6 ms), respectively. The off‐resonance estimates ranged from −60 to 30 Hz. TheR2from T2‐Prep bSSFP was 15.7 ± 1.7 Hz (T2 = 68.6 ± 8.6 ms) and from multi‐echo gradient echo was 131.2 ± 30.4 Hz ( = 8.0 ± 2.5 ms). Paired t‐test indicated that there is a significant difference between the proposed and reference methods (p < 0.05). The meanR2estimate from T2‐Prep bSSFP was slightly smaller than that from ES‐MCSE, whereas the mean and estimates from ES‐MCSE and multi‐echo gradient echo were similar to each other across all subjects. ConclusionsJoint estimation of transverse relaxation rates and off‐resonance is feasible at 0.55 T with a free‐breathing electrocardiogram‐gated and navigator‐gated ES‐MCSE sequence. At 0.55 T, the meanR2of 17.3 Hz is similar to the reported meanR2of 16.7 Hz at 1.5 T, but the mean of 127.5 Hz is about 5–10 times smaller than that reported at 1.5 T.
more »
« less
Submillimeter lung MRI at 0.55 T using balanced steady‐state free precession with half‐radial dual‐echo readout (bSTAR)
PurposeTo demonstrate the feasibility of high‐resolution morphologic lung MRI at 0.55 T using a free‐breathing balanced steady‐state free precession half‐radial dual‐echo imaging technique (bSTAR). MethodsSelf‐gated free‐breathing bSTAR (TE1/TE2/TR of 0.13/1.93/2.14 ms) lung imaging in five healthy volunteers and a patient with granulomatous lung disease was performed using a 0.55 T MR‐scanner. A wobbling Archimedean spiral pole (WASP) trajectory was used to ensure a homogenous coverage of k‐space over multiple breathing cycles. WASP uses short‐duration interleaves randomly tilted by a small polar angle and rotated by a golden angle about the polar axis. Data were acquired continuously over 12:50 min. Respiratory‐resolved images were reconstructed off‐line using compressed sensing and retrospective self‐gating. Reconstructions were performed with a nominal resolution of 0.9 mm and a reduced isotropic resolution of 1.75 mm corresponding to shorter simulated scan times of 8:34 and 4:17 min, respectively. Analysis of apparent SNR was performed in all volunteers and reconstruction settings. ResultsThe technique provided artifact‐free morphologic lung images in all subjects. The short TR of bSTAR in conjunction with a field strength of 0.55 T resulted in a complete mitigation of off‐resonance artifacts in the chest. Mean SNR values in healthy lung parenchyma for the 12:50 min scan were 3.6 ± 0.8 and 24.9 ± 6.2 for 0.9 mm and 1.75 mm reconstructions, respectively. ConclusionThis study demonstrates the feasibility of morphologic lung MRI with a submillimeter isotropic spatial resolution in human subjects with bSTAR at 0.55 T.
more »
« less
- Award ID(s):
- 1828736
- PAR ID:
- 10572553
- Publisher / Repository:
- Wiley
- Date Published:
- Journal Name:
- Magnetic Resonance in Medicine
- Volume:
- 90
- Issue:
- 5
- ISSN:
- 0740-3194
- Page Range / eLocation ID:
- 1949 to 1957
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
More Like this
-
-
Abstract PurposeTo demonstrate speech‐production real‐time MRI (RT‐MRI) using a contemporary 0.55T system, and to identify opportunities for improved performance compared with conventional field strengths. MethodsExperiments were performed on healthy adult volunteers using a 0.55T MRI system with high‐performance gradients and a custom 8‐channel upper airway coil. Imaging was performed using spiral‐based balancedSSFPand gradient‐recalled echo (GRE) pulse sequences using a temporal finite‐difference constrained reconstruction. Speech‐production RT‐MRI was performed with three spiral readout durations (8.90, 5.58, and 3.48 ms) to determine trade‐offs with respect to articulator contrast, blurring, banding artifacts, and overall image quality. ResultsBoth spiral GRE and bSSFP captured tongue boundary dynamics during rapid consonant‐vowel syllables. Although bSSFP provided substantially higher SNR in all vocal tract articulators than GRE, it suffered from banding artifacts at TR > 10.9 ms. Spiral bSSFP with the shortest readout duration (3.48 ms, TR = 5.30 ms) had the best image quality, with a 1.54‐times boost in SNR compared with an equivalent GRE sequence. Longer readout durations led to increased SNR efficiency and blurring in both bSSFP and GRE. ConclusionHigh‐performance 0.55T MRI systems can be used for speech‐production RT‐MRI. Spiral bSSFP can be used without suffering from banding artifacts in vocal tract articulators, provide better SNR efficiency, and have better image quality than what is typically achieved at 1.5 T or 3 T.more » « less
-
Abstract PurposeTo develop a robust single breath‐hold approach for volumetric lung imaging at 0.55T. MethodA balanced‐SSFP (bSSFP) pulse sequence with 3D stack‐of‐spiral (SoS) out‐in trajectory for volumetric lung imaging at 0.55T was implemented. With 2.7× undersampling, the pulse sequence enables imaging during a 17‐s breath‐hold. Image reconstruction is performed using 3D SPIRiT and 3D l1‐Wavelet regularizations. In two healthy volunteers, single breath‐hold SoS out‐in bSSFP was compared against stack‐of‐spiral UTE (spiral UTE) and half‐radial dual‐echo bSSFP (bSTAR), based on signal intensity (SI), blood‐lung parenchyma contrast, and image quality. In six patients with pathologies including lung nodules, fibrosis, emphysema, and air trapping, single breath‐hold SoS out‐in and bSTAR were compared against low‐dose computed tomography (LDCT). ResultsSoS out‐in bSSFP achieved 2‐mm isotropic resolution lung imaging with a single breath‐hold duration of 17 s. SoS out‐in (2‐mm isotropic) provided higher lung parenchyma and blood SI and blood‐lung parenchyma contrast compared to spiral UTE (2.4 × 2.4 × 2.5 mm3) and bSTAR (1.6‐mm isotropic). When comparing SI normalized by voxel size, SoS out‐in has lower lung parenchyma signal, higher blood signal, and a higher blood‐lung parenchyma contrast compared to bSTAR. In patients, SoS out‐in bSSFP was able to identify lung fibrosis and lung nodules of size 4 and 8 mm, and breath‐hold bSTAR was able to identify lung fibrosis and 8 mm nodules. ConclusionSingle breath‐hold volumetric lung imaging at 0.55T with 2‐mm isotropic spatial resolution is feasible using SoS out‐in bSSFP. This approach could be useful for rapid lung disease screening, and in cases where free‐breathing respiratory navigated approaches fail.more » « less
-
PurposeTo develop a novel method to achieve fast, high‐resolution, 3D multi‐TE1H‐MRSI of the brain. MethodsA new multi‐TE MRSI acquisition strategy was developed that integrates slab selective excitation with adiabatic refocusing for better volume coverage, rapid spatiospectral encoding, sparse multi‐TE sampling, and interleaved water navigators for field mapping and calibration. Special data processing strategies were developed to interpolate the sparsely sampled data, remove nuisance signals, and reconstruct multi‐TE spatiospectral distributions with high SNR. Phantom and in vivo experiments have been carried out to demonstrate the capability of the proposed method. ResultsThe proposed acquisition can produce multi‐TE1H‐MRSI data with three TEs at a nominal spatial resolution of 3.4 × 3.4 × 5.3 mm3in around 20 min. High‐SNR brain metabolite spatiospectral reconstructions can be obtained from both a metabolite phantom and in vivo experiments by the proposed method. ConclusionHigh‐resolution, 3D multi‐TE1H‐MRSI of the brain can be achieved within clinically feasible time. This capability, with further optimizations, could be translated to clinical applications and neuroscience studies where simultaneously mapping metabolites and neurotransmitters and TE‐dependent molecular spectral changes are of interest.more » « less
-
Abstract PurposeBreath‐held fat‐suppressed volumetric T1‐weighted MRI is an important and widely‐used technique for evaluating the abdomen. Both fat‐saturation and Dixon‐based fat‐suppression methods are used at conventional field strengths; however, both have challenges at lower field strengths (<1.5T) due to insufficient fat suppression and/or inadequate resolution. Specifically, at lower field strengths, fat saturation often fails due to the short T1 of lipid; and Cartesian Dixon imaging provides poor spatial resolution due to the need for a long ∆TE, due to the smaller ∆f between water and lipid. The purpose of this work is to demonstrate a new approach capable of simultaneously achieving excellent fat suppression and high spatial resolution on a 0.55T whole‐body system. MethodsWe applied 3D stack‐of‐spirals Dixon imaging at 0.55T, with compensation of concomitant field phase during reconstruction. The spiral readouts make efficient use of the requisite ∆TE. We compared this with 3D Cartesian Dixon imaging. Experiments were performed in 2 healthy and 10 elevated liver fat volunteers. ResultsStack‐of‐spirals Dixon imaging at 0.55T makes excellent use of the required ∆TE, provided high SNR efficiency and finer spatial resolution (1.7 × 1.7 × 5 mm3) compared Cartesian Dixon (3.5 × 3.5 × 5 mm3), within a 17‐s breath‐hold. We observed successful fat suppression, and improved definition of structures such as the liver, kidneys, and bowel. ConclusionWe demonstrate that high‐resolution single breath‐hold volumetric abdominal T1‐weighted imaging is feasible at 0.55T using spiral sampling and concomitant field correction. This is an attractive alternative to existing Cartesian‐based methods, as it simultaneously provides high‐resolution and excellent fat‐suppression.more » « less