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Title: Engineering disease analyte response in peptide self-assembly
A need to enhance the precision and specificity of therapeutic nanocarriers inspires the development of advanced nanomaterials capable of sensing and responding to disease-related cues. Self-assembled peptides offer a promising nanocarrier platform with versatile use to create precisely defined nanoscale materials. Disease-relevant cues can range from large biomolecules, such as enzymes, to ubiquitous small molecules with varying concentrations in healthy versus diseased states. Notably, pH changes (i.e., H+ concentration), redox species (e.g., H2O2), and glucose levels are significant spatial and/or temporal indicators of therapeutic needs. Self-assembled peptides respond to these cues by altering their solubility, modulating electrostatic interactions, or facilitating chemical transformations through dynamic or labile bonds. This review explores the design and construction of therapeutic nanocarriers using self-assembled peptides, focusing on how peptide sequence engineering and the inclusion of non-peptidic components can link the assembly state of these nanocarriers to the presence of disease-relevant small molecules.  more » « less
Award ID(s):
1944875
PAR ID:
10577907
Author(s) / Creator(s):
;
Publisher / Repository:
Royal Society of Chemistry
Date Published:
Journal Name:
Journal of Materials Chemistry B
Volume:
12
Issue:
42
ISSN:
2050-750X
Page Range / eLocation ID:
10757 to 10769
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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