More Like this

1. Flexible Nanoparticles Reach Sterically Obscured Endothelial Targets Inaccessible to Rigid Nanoparticles

   https://doi.org/10.1002/adma.201802373  

   Myerson, Jacob W.; Braender, Bruce; Mcpherson, Olivia; Glassman, Patrick M.; Kiseleva, Raisa Y.; Shuvaev, Vladimir V.; Marcos-Contreras, Oscar; Grady, Martha E.; Lee, Hyun-Su; Greineder, Colin F.; et al (June 2018, Advanced Materials)

   Molecular targeting of nanoparticle drug carriers promises maximized therapeutic impact to sites of disease or injury with minimized systemic effects. Precise targeting demands addressing to subcellular features. Caveolae, invaginations in cell membranes implicated in transcytosis and inflammatory signaling, are appealing subcellular targets. Caveolar geometry has been reported to impose a ≈50 nm size cutoff on nanocarrier access to plasmalemma vesicle associated protein (PLVAP), a marker found in caveolae in the lungs. The use of deformable nanocarriers to overcome that size cutoff is explored in this study. Lysozyme-dextran nanogels (NGs) are synthesized with ≈150 or ≈300 nm mean diameter. Atomic force microscopy indicates the NGs deform on complementary surfaces. Quartz crystal microbalance data indicate that NGs form softer monolayers (≈60 kPa) than polystyrene particles (≈8 MPa). NGs deform during flow through microfluidic channels, and modeling of NG extrusion through porous filters yields sieving diameters less than 25 nm for NGs with 150 and 300 nm hydrodynamic diameters. NGs of 150 and 300 nm diameter target PLVAP in mouse lungs while counterpart rigid polystyrene particles do not. The data in this study indicate a role for mechanical deformability in targeting large high-payload drug-delivery vehicles to sterically obscured targets like PLVAP. 

   more » « less
2. Chiromagnetic nanoparticles and gels

   https://doi.org/10.1126/science.aao7172  

   Yeom, Jihyeon; Santos, Uallisson S.; Chekini, Mahshid; Cha, Minjeong; de Moura, André F.; Kotov, Nicholas A. (January 2018, Science)
3. Metal-Organic Framework Nanoparticles

   https://doi.org/10.1002/adma.201800202  

   Wang, Shunzhi; McGuirk, C. Michael; d'Aquino, Andrea; Mason, Jarad A.; Mirkin, Chad A. (June 2018, Advanced Materials)

   Due to their well-defined 3D architectures, permanent porosity, and diverse chemical functionalities, metal–organic framework nanoparticles (MOF NPs) are an emerging class of modular nanomaterials. Herein, recent developments in the synthesis and postsynthetic surface functionalization of MOF NPs that strengthen the fundamental understanding of how such structures form and grow are highlighted; the internal structure and external surface properties of these novel nanomaterials are highlighted as well. These fundamental advances have resulted in MOF NPs being used as components in chemical sensors, biological probes, and membrane separation materials, as well as building blocks for colloidal crystal engineering. 

   more » « less
4. Bioimaging with Upconversion Nanoparticles

   https://doi.org/10.1002/adpr.202200098  

   Mettenbrink, Evan M.; Yang, Wen; Wilhelm, Stefan (December 2022, Advanced Photonics Research)
5. Nanoparticles in Joint Arthroplasties

   https://doi.org/10.1142/S1793984423300017  

   Thomson, Rebecca J.; Limberg, Afton K.; Van Citters, Douglas W. (March 2023, Nano LIFE)

   Joint arthroplasty, specifically total knee arthroplasty (TKA) and total hip arthroplasty (THA), are two of the highest value surgical procedures. Over the last several decades, the materials utilized in these surgeries have improved and increased device longevity. However, with an increased incidence of TKA and THA surgeries in younger patients, it is crucial to make these materials more durable. The addition of nanoparticles is one technology that is being explored for this purpose. This review focuses on the addition of nanoparticles to the various parts of arthroplasty surgery comprising of the metallic, ceramic, or polyethylene components along with the bone cement used for fixation. Carbon additives proved to be the most widely studied, and could potentially reduce stress shielding, improve wear, and enhance the biocompatibility of arthroplasty implants. 

   more » « less