Pancreatic Ductal Adenocarcinoma (PDAC) is regarded as one of the most lethal cancer typesfor its challenges associated with early diagnosis and resistance to standard chemotherapeutic agents,thereby leading to a poor five-year survival rate. The complexity of the disease calls for a multidisciplinaryapproach to better manage the disease and improve the status quo in PDAC diagnosis, prognosis,and treatment. To this end, the application of quantitative tools can help improve the understanding ofdisease mechanisms, develop biomarkers for early diagnosis, and design patient-specific treatment strategiesto improve therapeutic outcomes. However, such approaches have only been minimally applied towardsthe investigation of PDAC, and we review the current status of mathematical modeling works inthis field.
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Pancreatic Ductal Adenocarcinoma (PDAC): A Review of Recent Advancements Enabled by Artificial Intelligence
Pancreatic Ductal Adenocarcinoma (PDAC) remains one of the most formidable challenges in oncology, characterized by its late detection and poor prognosis. Artificial intelligence (AI) and machine learning (ML) are emerging as pivotal tools in revolutionizing PDAC care across various dimensions. Consequently, many studies have focused on using AI to improve the standard of PDAC care. This review article attempts to consolidate the literature from the past five years to identify high-impact, novel, and meaningful studies focusing on their transformative potential in PDAC management. Our analysis spans a broad spectrum of applications, including but not limited to patient risk stratification, early detection, and prediction of treatment outcomes, thereby highlighting AI’s potential role in enhancing the quality and precision of PDAC care. By categorizing the literature into discrete sections reflective of a patient’s journey from screening and diagnosis through treatment and survivorship, this review offers a comprehensive examination of AI-driven methodologies in addressing the multifaceted challenges of PDAC. Each study is summarized by explaining the dataset, ML model, evaluation metrics, and impact the study has on improving PDAC-related outcomes. We also discuss prevailing obstacles and limitations inherent in the application of AI within the PDAC context, offering insightful perspectives on potential future directions and innovations.
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- Award ID(s):
- 2234468
- PAR ID:
- 10599138
- Publisher / Repository:
- MDPI
- Date Published:
- Journal Name:
- Cancers
- Volume:
- 16
- Issue:
- 12
- ISSN:
- 2072-6694
- Page Range / eLocation ID:
- 2240
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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