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Abstract Isochromenes are important pharmacophores present in biologically active molecules and natural products. Their synthesis is generally limited to cyclization of phenyl propargyl ether precursors under transition metal catalyzed conditions. Herein, we present a novel disconnection that rapidly constructs isochromene derivatives through a cascade radical cyclization strategy. Generation of aryl radicals by SET reduction of 2‐iodo benzyl allenyl ethers is followed by radical cyclization to construct the isochromene core with formation of an allylic radical. The allylic radical then undergoes coupling with the azaallyl radical to give products in good to excellent yields. The elaborated 2‐iodo phenyl propargyl ether precursors can be used to construct isochromenes bearing various functional groups. magnified image
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This content will become publicly available on March 25, 2026
Topology and Mechanical Properties of Polymer Networks Formed under Free Radical and Atom Transfer Radical Polymerizations
- Award ID(s):
- 2225167
- PAR ID:
- 10614033
- Publisher / Repository:
- ACS
- Date Published:
- Journal Name:
- Macromolecules
- Volume:
- 58
- Issue:
- 6
- ISSN:
- 0024-9297
- Page Range / eLocation ID:
- 3168 to 3187
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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