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This content will become publicly available on August 1, 2026

Title: Recent advances in understanding of the mechanisms of RNA interference in insects
Abstract We highlight the recent 5 years of research that contributed to our understanding of the mechanisms of RNA interference (RNAi) in insects. Since its first discovery, RNAi has contributed enormously as a reverse genetic tool for functional genomic studies. RNAi is also being used in therapeutics, as well as agricultural crop and livestock production and protection. Yet, for the wider application of RNAi, improvement of its potency and delivery technologies is needed. A mechanistic understanding of every step of RNAi, from cellular uptake of RNAi trigger molecules to targeted mRNA degradation, is key for developing an efficient strategy to improve RNAi technology. Insects provide an excellent model for studying the mechanism of RNAi due to species‐specific variations in RNAi efficiency. This allows us to perform comparative studies in insect species with different RNAi sensitivity. Understanding the mechanisms of RNAi in different insects can lead to the development of better strategies to improve RNAi and its application to manage agriculturally and medically important insects.  more » « less
Award ID(s):
1821936
PAR ID:
10627319
Author(s) / Creator(s):
;
Publisher / Repository:
Royal entomological Society
Date Published:
Journal Name:
Insect Molecular Biology
Volume:
34
Issue:
4
ISSN:
0962-1075
Page Range / eLocation ID:
491 to 504
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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