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1. Enzymatic synthesis of azide by a promiscuous N-nitrosylase

   https://doi.org/10.1038/s41557-024-01646-2  

   Del_Rio_Flores, Antonio; Zhai, Rui; Kastner, David W; Seshadri, Kaushik; Yang, Siyue; De_Matias, Kyle; Shen, Yuanbo; Cai, Wenlong; Narayanamoorthy, Maanasa; Do, Nicholas B; et al (December 2024, Nature Chemistry)
2. A Physical Organic Approach towards Statistical Modeling of Tetrazole and Azide Decomposition**

   https://doi.org/10.1002/anie.202218213  

   Rein, Jonas; Meinhardt, Jonathan M.; Hofstra Wahlman, Julie L.; Sigman, Matthew S.; Lin, Song (March 2023, Angewandte Chemie International Edition)

   Abstract Nitrogen atom‐rich heterocycles and organic azides have found extensive use in many sectors of modern chemistry from drug discovery to energetic materials. The prediction and understanding of their energetic properties are thus key to the safe and effective application of these compounds. In this work, we disclose the use of multivariate linear regression modeling for the prediction of the decomposition temperature and impact sensitivity of structurally diverse tetrazoles and organic azides. We report a data‐driven approach for property prediction featuring a collection of quantum mechanical parameters and computational workflows. The statistical models reported herein carry predictive accuracy as well as chemical interpretability. Model validation was successfully accomplished via tetrazole test sets with parameters generated exclusively in silico. Mechanistic analysis of the statistical models indicated distinct divergent pathways of thermal and impact‐initiated decomposition. 

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3. Azide-Functionalized Nanoclusters via a Ligand-Induced Rearrangement

   https://doi.org/10.1021/acs.chemmater.0c02347  

   Kang, Xi; Ren, Mengqi; Zhu, Manzhou; Zhang, Ke (August 2020, Chemistry of Materials)

   null (Ed.)
4. Synthesis of Polyphosphazenes by a Fast Perfluoroaryl Azide-Mediated Staudinger Reaction

   https://doi.org/10.1021/acs.macromol.8b00618  

   Sundhoro, Madanodaya; Park, Jaehyeung; Wu, Bin; Yan, Mingdi (June 2018, Macromolecules)
5. A “DROP-IN” COMPOSITE MATRIX VIA AZIDE-ALKYNE CYCLOADDITION

   Cooke, III R.; Brei, M. R.; VandeWalle, D. T.; Storey, R. F. (December 2017, CAMX: The Composites and Advanced Materials Expo)

   Since the inception of carbon fiber-reinforced polymers (CFRPs) they have steadily gained in popularity due to their light weight, high tensile strength and modulus, and environmental toughness. However, curing of CFRPs of the thermosetting type generally must be performed within an autoclave, whose fixed, physical dimensions effectively limit the maximum size of the part. Alternative curing chemistries may potentially eliminate the requirement for an autoclave, which would allow creation of much larger panels. This project seeks to develop a thermoset composite matrix that is radiation-curable using the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click reaction. Previously, Storey et al.(1,2) reported that the azide-modified epoxy resin, di(3-azido-2-hydroxypropyl) ether of bisphenol-A (DAHP-BPA), could be cured by reaction with polyfunctional alkyne crosslinkers under mild conditions using Cu(I) catalysis. In the absence of reducing agents, Cu(II) compounds are catalytically inactive; however, upon exposure to ultraviolet light, they are reduced to Cu(I), which then catalyzes the reaction, allowing it to progress to a high degree of cure at room temperature. Herein, we report the kinetics of photo-induced CuAAC polymerization of the DAHP-BPA and several polyfunctional propargyl amine based crosslinkers, monitored by real-time FTIR as well as mechanical properties of fully cured materials. Polymerizations were studied as a function of Cu(II) compound type, Cu(II) concentration, UV light (365 nm) intensity, and duration of irradiation. 

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