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Abstract As one of the noninvasive screening and diagnostic tools for human breath monitoring of various diseases, chemiresistive devices with nanomaterials as the sensing interfaces for detecting volatile organic compounds (VOCs) have attracted increasing interests. A key challenge for the practical applications is an effective integration of all components in a system level. By integrating with the system components, it provides reliable and rapid results as a fast‐screening method for healthcare, safety, and environmental monitoring. This paper highlights some of the latest developments in chemiresistive sensors designed for the detection of VOCs and human breaths. It begins with a brief introduction to the fundamental principles of chemiresistive sensors with nanoparticle‐structured sensing interfaces. This is followed by a discussion of the recent fabrication methods, with an emphasis on nanostructured materials. Some of the recent examples will be highlighted in terms of recent innovative approaches to sensor applications and system integrations. Challenges and opportunities will also be discussed for the advancement and refinement of the chemiresistive sensor technologies in breath screening and monitoring of diseases.
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This content will become publicly available on May 15, 2026
Monitoring Skin Volatile Emissions Using Wearable Sensors
Human skin emits a continuous flux of volatile compounds reflecting various metabolic processes in the body, microbial activity, and environmental factors. Harnessing this emission for diagnostics is of great interest given the noninvasive, passive, and accessible nature of the emission, and there is much research underway to understand the value of this skin-emitted volatile organic compound (VOC) matrix. In parallel to this, wearable skin VOC sensors are emerging and garnering attention due to their potential to provide noninvasive, real-time information for monitoring human health, overcoming many of the design challenges related to biofluid monitoring via wearables. The projected opportunities for skin VOCs are fueling innovations in wearable VOC monitoring. This review discusses the most recent developments, from fully integrated wearable skin VOC sensors that exploit existing semiconductor technology to the design and preparation of advanced new sensing materials and devices to deliver new modalities for wearable skin VOC sensors. We articulate the challenges, limitations, and opportunities for technological advances to provide a perspective on promising directions for future developments.
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- Award ID(s):
- 2139716
- PAR ID:
- 10635933
- Publisher / Repository:
- Annual Reviews
- Date Published:
- Journal Name:
- Annual Review of Analytical Chemistry
- Volume:
- 18
- Issue:
- 1
- ISSN:
- 1936-1327
- Page Range / eLocation ID:
- 285 to 305
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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