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A modular, nanoscale platform for the targeted delivery of camptothecin to cancer cells expressing TAG-72
In this work, a polydopamine-coated, camptothecin nanotube functionalized with a targeting anti-TAG-72 scFv exhibited enhanced cytotoxicity against TAG-72 positive, LS-174T colon cancer cells, compared with HT-29 cells negative for the antigen.
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- Award ID(s):
- 2106924
- PAR ID:
- 10641874
- Publisher / Repository:
- Royal Society of Chemistry
- Date Published:
- Journal Name:
- Biomaterials Science
- Volume:
- 13
- Issue:
- 19
- ISSN:
- 2047-4830
- Page Range / eLocation ID:
- 5352 to 5357
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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