Abstract We report the validation of multiple planets transiting the nearby (d= 12.8 pc) K5V dwarf HD 101581 (GJ 435, TOI–6276, TIC 397362481). This system consists of at least two Earth-size planets whose orbits are near a mutual 4:3 mean-motion resonance, HD 101581 b ( ,P= 4.47 days) and HD 101581c ( ,P= 6.21 days). Both planets were discovered in Sectors 63 and 64 TESS observations and statistically validated with supporting ground-based follow-up. We also identify a signal that probably originates from a third transiting planet, TOI-6276.03 ( ,P= 7.87 days). These planets are remarkably uniform in size and their orbits are evenly spaced, representing a prime example of the “peas-in-a-pod” architecture seen in other compact multiplanet systems. AtV= 7.77, HD 101581 is the brightest star known to host multiple transiting planets smaller than 1.5R⊕. HD 101581 is a promising system for atmospheric characterization and comparative planetology of small planets.
more »
« less
Efficient assessment of real-world dynamics of circadian rhythms in heart rate and body temperature from wearable data
Laboratory studies have made unprecedented progress in understanding circadian physiology. Quantifying circadian rhythms outside of laboratory settings is necessary to translate these findings into real-world clinical practice. Wearables have been considered promising way to measure these rhythms. However, their limited validation remains an open problem. One major barrier to implementing large-scale validation studies is the lack of reliable and efficient methods for circadian assessment from wearable data. Here, we propose an approximation-based least-squares method to extract underlying circadian rhythms from wearable measurements. Its computational cost is ∼ 300-fold lower than that of previous work, enabling its implementation in smartphones with low computing power. We test it on two large-scale real-world wearable datasets: of body temperature data from cancer patients and ∼ 184 000 days of heart rate and activity data collected from the ‘Social Rhythms’ mobile application. This shows successful extraction of real-world dynamics of circadian rhythms. We also identify a reasonable harmonic model to analyse wearable data. Lastly, we show our method has broad applicability in circadian studies by embedding it into a Kalman filter that infers the state space of the molecular clocks in tissues. Our approach facilitates the translation of scientific advances in circadian fields into actual improvements in health.
more »
« less
- Award ID(s):
- 2052499
- PAR ID:
- 10649720
- Publisher / Repository:
- Royal Society Interface
- Date Published:
- Journal Name:
- Journal of The Royal Society Interface
- Volume:
- 20
- Issue:
- 205
- ISSN:
- 1742-5662
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
More Like this
-
-
The use of multispectral geostationary satellites to study aquatic ecosystems improves the temporal frequency of observations and mitigates cloud obstruction, but no operational capability presently exists for the coastal and inland waters of the United States. The Advanced Baseline Imager (ABI) on the current iteration of the Geostationary Operational Environmental Satellites, termed the Series (GOES-R), however, provides sub-hourly imagery and the opportunity to overcome this deficit and to leverage a large repository of existing GOES-R aquatic observations. The fulfillment of this opportunity is assessed herein using a spectrally simplified, two-channel aquatic algorithm consistent with ABI wave bands to estimate the diffuse attenuation coefficient for photosynthetically available radiation, . First, anin situABI dataset was synthesized using a globally representative dataset of above- and in-water radiometric data products. Values of were estimated by fitting the ratio of the shortest and longest visible wave bands from thein situABI dataset to coincident,in situ data products. The algorithm was evaluated based on an iterative cross-validation analysis in which 80% of the dataset was randomly partitioned for fitting and the remaining 20% was used for validation. The iteration producing the median coefficient of determination ( ) value (0.88) resulted in a root mean square difference of , or 8.5% of the range in the validation dataset. Second, coincident mid-day images of central and southern California from ABI and from the Moderate Resolution Imaging Spectroradiometer (MODIS) were compared using Google Earth Engine (GEE). GEE default ABI reflectance values were adjusted based on a near infrared signal. Matchups between the ABI and MODIS imagery indicated similar spatial variability ( ) between ABI adjusted blue-to-red reflectance ratio values and MODIS default diffuse attenuation coefficient for spectral downward irradiance at 490 nm, , values. This work demonstrates that if an operational capability to provide ABI aquatic data products was realized, the spectral configuration of ABI would potentially support a sub-hourly, visible aquatic data product that is applicable to water-mass tracing and physical oceanography research.more » « less
-
Abstract This work presents MARS (Modular apparatus for nuclear reactions spectroscopy) and its characterization prior to its first application to measure$$^6$$ Li+$$^{12}$$ C nuclear reactions. Measurements were performed at the 3 MV tandem accelerator of the CNA (National Accelerator Center), in Seville, Spain. The$$^{6}$$ Li projectiles were accelerated at energies around the$$^6$$ Li+$$^{12}$$ C Coulomb barrier ($$V^{\text {cm}}_{B}\sim 3.0$$ MeV - center of mass and$$V^{\text {lab}}_{B}\sim 4.5$$ MeV - laboratory frame). Using a$$^{6}\hbox {Li}^{2+}$$ beam, we measured at 13 laboratory energies from 4.00 to 7.75 MeV. Thus, we present the excitation function of$$^{12}$$ C($$^6$$ Li,$$^4$$ He)$$^{14}\hbox {N}^{g.s.}$$ reaction, at 2 backward angles ($$110.0^\circ $$ and$$140.0^\circ $$ ). The projectile dissociation, leading to this reaction, increases with the bombarding energies around the Coulomb barrier. This dissociation is favored at an optimum energy$$E_{b}^{\text {op}}$$ $$\ge $$ $$V_{B}$$ +$$|Q_{bu}|$$ , where$$V_{B}$$ is the Coulomb barrier of the system, and$$|Q_{bu}|$$ is the module ofQ-value for the$$^6$$ Li dissociation into$$^4$$ He+$$^2$$ H. This result corroborates a systematic analysis of weakly bound projectiles reacting on several targets [1].more » « less
-
Kähler, C; Longmire, E; Westerweel, J (Ed.)Abstract A direct comparison of the droplet size and number measurements using in-line holography and shadow imaging is presented in three dynamically evolving laboratory scale experiments. The two experimental techniques and image processing algorithms used to measure droplet number and radii are described in detail. Droplet radii as low as$$r = 14$$ µm are measured using in-line holography and$$r = 50$$ µm using shadow imaging. The droplet radius measurement error is estimated using a calibration target (reticle) and it was found that the holographic technique is able to measure droplet radii more accurately than shadow imaging for droplets with$$r \le 625$$ µm. Using the measurements of droplet number and size we quantitatively cross-validate and assess the accuracy of the two measurement techniques. The droplet size distributions,N(r), are measured in all three experiments and are found to agree well between the two measurement techniques. In one of the laboratory experiments, simultaneous measurements of droplets ($$r \ge 14$$ µm, using holography) and dry aerosols ($$0.07 \lessapprox r \lessapprox 2$$ µm, using an scanning mobility particle sizer and$$0.15 \lessapprox r \lessapprox 5$$ µm using an optical particle sizer) are reported, one of the first such comparison to the best of our knowledge. The total number and volume of droplets is found to agree well between both techniques in the three experiments. We demonstrate that a relatively simple shadow imaging technique can be just as reliable when compared to a more sophisticated holographic measurement technique over their common droplet radius measurement range. The agreement in results is shown to be valid over a large range of droplet concentrations, which include experiments with relatively sparse droplet concentrations as low as 0.02 droplets per image. Advantages and disadvantages for the two techniques are discussed in the context of our results. The main advantages to in-line holography are the greater accuracy in droplet radius measurement, greater spatial resolution, larger depth of field, and the high repetition rate and short pulse duration of the laser light source. In comparison, the main advantages to shadow imaging are the simpler experimental setup, image processing algorithm, and fewer computer resources necessary for image processing. Droplet statistics like number and size are found to be very reliable between the two methods for large range of droplet densities,$${\mathcal {P}}_{r>50}$$ , ranging from$$10^{-4} \le {\mathcal {P}}_{r>50} \le 10^{-1}$$ cm$$^{-3}$$ , when the two techniques are implemented as shown in this paper.more » « less
-
Abstract Brown dwarfs bridge the gap between stars and planets, providing valuable insight into both planetary and stellar-formation mechanisms. Yet the census of transiting brown-dwarf companions, in particular around M-dwarf stars, remains incomplete. We report the discovery of two transiting brown dwarfs around low-mass hosts using a combination of space- and ground-based photometry along with near-infrared radial velocities. We characterize TOI-5389Ab ( ) and TOI-5610b ( ), two moderately massive brown dwarfs orbiting early M-dwarf hosts (Teff = 3569 ± 59 K and 3618 ± 59 K, respectively). For TOI-5389Ab, the best fitting parameters are periodP = 10.40046 ± 0.00002 days, radius RJ, and low eccentricity . In particular, this constitutes one of the most extreme substellar-stellar companion-to-host mass ratios ofq= 0.150. For TOI-5610b, the best-fitting parameters are periodP = 7.95346 ± 0.00002 days, radius RJ, and moderate eccentricity . Both targets are expected to have shallow, but potentially observable, occultations: ≲500 ppm in the JohnsonKband. A statistical analysis of M-dwarf/BD systems reveals for the first time that those at short orbital periods (P < 13 days) exhibit a dearth of 13MJ < MBD < 40MJcompanions (q < 0.1) compared to those at slightly wider separations.more » « less
An official website of the United States government

