Machine learning to evaluate the effects of non-clinical social determinant features in predicting colorectal Cancer mortality in a medically underserved Appalachian population

Montgomery, Aisha (ORCID:0000000301753437); Vadapalli, Ravi (ORCID:0000000289253244); Dinenno, Frank A (ORCID:0000000346443213); Schilling, Josh (ORCID:0000000213677008); Jain, Praduman (ORCID:0000000200627044); Jacob, Aasems (ORCID:0000000277833786); Chism, David (ORCID:0009000744232718); Shanker, Anil (ORCID:0000000163723669)

doi:10.1038/s41598-025-11074-y

Merit is a central pillar of liberal epistemology, humanism, and democracy. The scientific enterprise, built on merit, has proven effective in generating scientific and technological advances, reducing suffering, narrowing social gaps, and improving the quality of life globally. This perspective documents the ongoing attempts to undermine the core principles of liberal epistemology and to replace merit with non-scientific, politically motivated criteria. We explain the philosophical origins of this conflict, document the intrusion of ideology into our scientific institutions, discuss the perils of abandoning merit, and offer an alternative, human-centered approach to address existing social inequalities.

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