This content will become publicly available on September 1, 2026

Title: COMMA: A Communicative Multimodal Multi-Agent Benchmark
The rapid advances of multimodal agents built on large foundation models have largely overlooked their potential for language-based communication between agents in collaborative tasks. This oversight presents a critical gap in understanding their effectiveness in real-world deployments, particularly when communicating with humans. Existing agentic benchmarks fail to address key aspects of inter-agent communication and collaboration, particularly in scenarios where agents have unequal access to information and must work together to achieve tasks beyond the scope of individual capabilities. To fill this gap, we introduce COMMA: a novel puzzle benchmark designed to evaluate the collaborative performance of multimodal multi-agent systems through language communication. Our benchmark features a variety of multimodal puzzles, providing a comprehensive evaluation across four key categories of agentic capability in a communicative collaboration setting. Our findings reveal surprising weaknesses in state-of-the-art models, including strong proprietary models like GPT-4o and reasoning models like o4-mini. Many chain of thought reasoning models such as R1-Onevision and LLaVA-CoT struggle to outperform even a random baseline in agent-agent collaboration, indicating a potential growth area in their communication abilities.  more » « less
Award ID(s):
2449768
PAR ID:
10685946
Author(s) / Creator(s):
; ; ; ; ;
Publisher / Repository:
Transactions on Machine Learning Research
Date Published:
Journal Name:
Transactions on machine learning research
ISSN:
2835-8856
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
More Like this
  1. Despite the significant advancements in the field of Natural Language Processing (NLP), Large Language Models (LLMs) have shown limitations in performing complex tasks that require arithmetic, commonsense, and symbolic reasoning. Reasoning frameworks like ReAct, Chain-of-thought (CoT), Tree-of-thoughts (ToT), etc. have shown success but with limitations in solving long-form complex tasks. To address this, we propose a knowledge-sharing and collaborative multi-agent assisted framework on LLMs that leverages the capabilities of existing reasoning frameworks and the collaborative skills of multi-agent systems (MASs). The objectives of the proposed framework are to overcome the limitations of LLMs, enhance their reasoning capabilities, and improve their performance in complex tasks. It involves generating natural language rationales and in-context few-shot learning via prompting, and integrates the reasoning techniques with efficient knowledge-sharing and communication driven agent networks. The potential benefits of the proposed framework include saving time and money, improved efficiency for computationally intensive reasoning, and the ability to incorporate multiple collaboration strategies for dynamically changing environments. 
    more » « less
  2. Abstract Large language models (LLMs) are evolving from passive predictors into agentic systems capable of planning, tool-use, and multimodal reasoning. This shift is especially consequential for biology, where complex, noisy, and multi-scale data require adaptive and integrative computational strategies. In this review, we provide the first systematic synthesis of LLM-based agents across genomics, molecular biology, imaging, biomedical analysis, and automated bioinformatics workflows. We analyze >60 emerging systems and organize them within a unifying framework that characterizes agentic traits, such as autonomous decision-making, external tool invocation, memory, and self-correction. Across domains, agentic LLMs show early promise in enabling multi-step analysis, linking heterogeneous evidence, and supporting exploratory scientific tasks. At the same time, our comparative assessment highlights consistent challenges, including unstable reasoning, limited biological grounding, retrieval misalignment, and barriers to reproducibility and biosafety. We conclude by outlining opportunities for trustworthy and collaborative biological agents, including multimodal integration, closed-loop experimental design, and robust evaluation practices. This survey aims to clarify the emerging landscape and chart a path toward reliable agentic systems for biological discovery. 
    more » « less
  3. The convergence of Agentic Artificial Intelligence (AI) and Multi-Agent Systems (MAS) enables a new paradigm for intelligent decision-making in Smart Manufacturing Systems (SMS). Traditional MAS architectures emphasize distributed coordination and specialized autonomy, while recent advances in agentic AI driven by Large Language Models (LLMs) introduce higher-order reasoning, planning, and tool orchestration capabilities. This paper presents a hybrid agentic AI and multi-agent framework for a Prescriptive Maintenance (RxM) use case, where LLM-based agents provide strategic orchestration and adaptive reasoning, complemented by rule-based and Small Language Models (SLMs) agents performing efficient, domain-specific tasks on the edge. The proposed framework adopts a layered architecture that consists of perception, preprocessing, analytics, and optimization layers, coordinated through an LLM Planner Agent that manages workflow decisions and context retention. Specialized agents autonomously handle schema discovery, intelligent feature analysis, model selection, and prescriptive optimization, while a human-in-the-loop interface ensures transparency and auditability of generated maintenance recommendations. This hybrid approach enables dynamic model adaptation, transparent decision-making, and cost-aware maintenance scheduling based on data-driven insights. An initial proof-of-concept implementation is validated on two industrial manufacturing datasets. The developed framework is modular and extensible, allowing new agents or domain-specific modules to be integrated seamlessly as system capabilities evolve. The results demonstrate the system’s capability to automatically detect schema, adapt preprocessing pipelines, optimize model performance through adaptive intelligence, and generate actionable, prioritized maintenance recommendations. The framework shows promise in achieving improved robustness, scalability, and explainability for RxM in smart manufacturing, bridging the gap between high-level agentic reasoning and low-level autonomous execution. 
    more » « less
  4. The adoption of large language models (LLMs) in healthcare has garnered significant research interest, yet their performance remains limited due to a lack of domain‐specific knowledge, medical reasoning skills, and their unimodal nature, which restricts them to text‐only inputs. To address these limitations, we propose MultiMedRes, a multimodal medical collaborative reasoning framework that simulates human physicians’ communication by incorporating a learner agent to proactively acquire information from domain‐specific expert models. MultiMedRes addresses medical multimodal reasoning problems through three steps i) Inquire: The learner agent decomposes complex medical reasoning problems into multiple domain‐specific sub‐problems; ii) Interact: The agent engages in iterative “ask‐answer” interactions with expert models to obtain domain‐specific knowledge; and iii) Integrate: The agent integrates all the acquired domain‐specific knowledge to address the medical reasoning problems (e.g., identifying the difference of disease levels and abnormality sizes between medical images). We validate the effectiveness of our method on the task of difference visual question answering for X‐ray images. The experiments show that our zero‐shot prediction achieves state‐of‐the‐art performance, surpassing fully supervised methods, which demonstrates that MultiMedRes could offer trustworthy and interpretable assistance to physicians in monitoring the treatment progression of patients, paving the way for effective human–AI interaction and collaboration. 
    more » « less
  5. Multimodal Large Language Models (MLLMs) have demonstrated impressive abilities across various tasks, including visual question answering and chart comprehension, yet existing benchmarks for chart-related tasks fall short in capturing the complexity of real-world multi-chart scenarios. Current benchmarks primarily focus on single-chart tasks, neglecting the multi-hop reasoning required to extract and integrate information from multiple charts, which is essential in practical applications. To fill this gap, we introduce MultiChartQA, a benchmark that evaluates MLLMs’ capabilities in four key areas: direct question answering, parallel question answering, comparative reasoning, and sequential reasoning. Our evaluation of a wide range of MLLMs reveals significant performance gaps compared to humans. These results highlight the challenges in multi-chart comprehension and the potential of MultiChartQA to drive advancements in this field. Our code and data are available at https://github.com/Zivenzhu/Multi-chart-QA. 
    more » « less