%ALiu, Keyin [State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China]%ALiu, Keyin [State Key Laboratory of Transducer Technology; Shanghai Institute of Microsystem and Information Technology; Chinese Academy of Sciences; Shanghai 200050 China]%AShi, Zhifeng [Department of Neurosurgery Huashan Hospital of Fudan University Shanghai 200040 China]%AShi, Zhifeng [Department of Neurosurgery; Huashan Hospital of Fudan University; Shanghai 200040 China]%AZhang, Shaoqing [Department of Mechanical Engineering the University of Texas at Austin Austin TX 78712 USA]%AZhang, Shaoqing [Department of Mechanical Engineering; the University of Texas at Austin; Austin TX 78712 USA]%AZhou, Zhitao [State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China, School of Graduate Study University of Chinese Academy of Sciences Beijing 100049 China]%AZhou, Zhitao [State Key Laboratory of Transducer Technology; Shanghai Institute of Microsystem and Information Technology; Chinese Academy of Sciences; Shanghai 200050 China; School of Graduate Study; University of Chinese Academy of Sciences; Beijing 100049 China]%ASun, Long [State Key Laboratory of Transducer Technology; Shanghai Institute of Microsystem and Information Technology; Chinese Academy of Sciences; Shanghai 200050 China]%ASun, Long [State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China]%AXu, Tao [Department of Neurosurgery Huashan Hospital of Fudan University Shanghai 200040 China]%AXu, Tao [Department of Neurosurgery; Huashan Hospital of Fudan University; Shanghai 200040 China]%AZhang, Yeshun [Sericultural Research Institute; College of Biotechnology; Jiangsu University of Science and Technology; Zhenjiang Jiangsu 212003 China]%AZhang, Yeshun [Sericultural Research Institute College of Biotechnology Jiangsu University of Science and Technology Zhenjiang Jiangsu 212003 China]%AZhang, Guozheng [Sericultural Research Institute College of Biotechnology Jiangsu University of Science and Technology Zhenjiang Jiangsu 212003 China]%AZhang, Guozheng [Sericultural Research Institute; College of Biotechnology; Jiangsu University of Science and Technology; Zhenjiang Jiangsu 212003 China]%ALi, Xinxin [State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China, School of Graduate Study University of Chinese Academy of Sciences Beijing 100049 China, School of Physical Science and Technology ShanghaiTech University Shanghai 200031 China]%ALi, Xinxin [State Key Laboratory of Transducer Technology; Shanghai Institute of Microsystem and Information Technology; Chinese Academy of Sciences; Shanghai 200050 China; School of Graduate Study; University of Chinese Academy of Sciences; Beijing 100049 China; School of Physical Science and Technology; ShanghaiTech University; Shanghai 200031 China]%AChen, Liang [Department of Neurosurgery Huashan Hospital of Fudan University Shanghai 200040 China]%AChen, Liang [Department of Neurosurgery; Huashan Hospital of Fudan University; Shanghai 200040 China]%AMao, Ying [Department of Neurosurgery; Huashan Hospital of Fudan University; Shanghai 200040 China]%AMao, Ying [Department of Neurosurgery Huashan Hospital of Fudan University Shanghai 200040 China]%ATao, Tiger [State Key Laboratory of Transducer Technology; Shanghai Institute of Microsystem and Information Technology; Chinese Academy of Sciences; Shanghai 200050 China; Department of Mechanical Engineering; the University of Texas at Austin; Austin TX 78712 USA; School of Graduate Study; University of Chinese Academy of Sciences; Beijing 100049 China; School of Physical Science and Technology; ShanghaiTech University; Shanghai 200031 China]%ATao, Tiger [State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China, Department of Mechanical Engineering the University of Texas at Austin Austin TX 78712 USA, School of Graduate Study University of Chinese Academy of Sciences Beijing 100049 China, School of Physical Science and Technology ShanghaiTech University Shanghai 200031 China]%BJournal Name: Advanced Healthcare Materials; Journal Volume: 7; Journal Issue: 6; Related Information: CHORUS Timestamp: 2023-08-25 18:39:49 %D2018%IWiley Blackwell (John Wiley & Sons) %JJournal Name: Advanced Healthcare Materials; Journal Volume: 7; Journal Issue: 6; Related Information: CHORUS Timestamp: 2023-08-25 18:39:49 %K %MOSTI ID: 10056068 %PMedium: X %TA Silk Cranial Fixation System for Neurosurgery %XAbstract

Cranial fixation should be safe, reliable, ideally degradable, and produce no hazardous residues and no artifacts on neuroimaging. Protein‐based fixation devices offer an exciting opportunity for this application. Here, the preclinical development and in vivo efficacy verification of a silk cranial fixation system in functional models are reported by addressing key challenges toward clinical use. A comprehensive study on this fixation system in rodent and canine animal models for up to 12 months is carried out. The silk fixation system shows a superb performance on the long‐term stability of the internal structural support for cranial flap fixation and bone reconnection and has good magnetic resonance imaging compatibility, and tolerability to high dose radiotherapy, underscoring the favorable clinical application of this system for neurosurgery compared to the current gold standard.

%0Journal Article