%ALu, Ming-Zhu%AChen, Xing-Rong%AXu, Hui%ADai, Hui-Xiong%AYu, Jin-Quan%BJournal Name: Chemical Science; Journal Volume: 9; Journal Issue: 5 %D2018%I %JJournal Name: Chemical Science; Journal Volume: 9; Journal Issue: 5 %K %MOSTI ID: 10169132 %PMedium: X %TLigand-enabled ortho -C–H olefination of phenylacetic amides with unactivated alkenes %XAlthough chelation-assisted C–H olefination has been intensely investigated, Pd( ii )-catalyzed C–H olefination reactions are largely restricted to acrylates and styrenes. Here we report a quinoline-derived ligand that enables the Pd( ii )-catalyzed olefination of the C(sp 2 )–H bond with simple aliphatic alkenes using a weakly coordinating monodentate amide auxiliary. Oxygen is used as the terminal oxidant with catalytic copper as the co-oxidant. A variety of functional groups in the aliphatic alkenes are tolerated. Upon hydrogenation, the ortho -alkylated product can be accessed. The utility of this reaction is also demonstrated by the late-stage diversification of drug molecules. %0Journal Article