%ALi, Yang%AShafipour, Rasoul%AMateos, Gonzalo%AZhang, Zhengwu%Anull Ed.%D2020%I %K %MOSTI ID: 10222998 %PMedium: X %TSupervised Graph Representation Learning for Modeling the Relationship between Structural and Functional Brain Connectivity %XIn this paper, we propose a supervised graph representation learning method to model the relationship between brain functional connectivity (FC) and structural connectivity (SC) through a graph encoder-decoder system. The graph convolutional network (GCN) model is leveraged in the encoder to learn lower-dimensional node representations (i.e. node embeddings) integrating information from both node attributes and network topology. In doing so, the encoder manages to capture both direct and indirect interactions between brain regions in the node embeddings which later help reconstruct empirical FC networks. From node embeddings, graph representations are learnt to embed the entire graphs into a vector space. Our end-to-end model utilizes a multi-objective loss function to simultaneously learn node representations for FC network reconstruction and graph representations for subject classification. The experiment on a large population of non-drinkers and heavy drinkers shows that our model can provide a characterization of the population pattern in the SC-FC relationship, while also learning features that capture individual uniqueness for subject classification. The identified key brain subnetworks show significant between-group difference and support the promising prospect of GCN-based graph representation learning on brain networks to model human brain activity and function. Country unknown/Code not availablehttps://doi.org/10.1109/ICASSP40776.2020.9053711OSTI-MSA