%ARego, Bruno%AKhalighi, Amir%ALai, Eric%AGorman, Robert%AGorman, III, Joseph%ASacks, Michael%BJournal Name: Scientific Reports; Journal Volume: 12; Journal Issue: 1; Related Information: CHORUS Timestamp: 2022-10-30 01:09:47 %D2022%INature Publishing Group %JJournal Name: Scientific Reports; Journal Volume: 12; Journal Issue: 1; Related Information: CHORUS Timestamp: 2022-10-30 01:09:47 %K %MOSTI ID: 10377149 %PMedium: X %TIn vivo assessment of mitral valve leaflet remodelling following myocardial infarction %X
Each year, more than 40,000 people undergo mitral valve (MV) repair surgery domestically to treat regurgitation caused by myocardial infarction (MI). Although continual MV tissue remodelling following repair is believed to be a major contributor to regurgitation recurrence, the effects of the post-MI state on MV remodelling remain poorly understood. This lack of understanding limits our ability to predict the remodelling of the MV both post-MI and post-surgery to facilitate surgical planning. As a necessary first step, the present study was undertaken to noninvasively quantify the effects of MI on MV remodelling in terms of leaflet geometry and deformation. MI was induced in eight adult Dorset sheep, and real-time three-dimensional echocardiographic (rt-3DE) scans were collected pre-MI as well as at 0, 4, and 8 weeks post-MI. A previously validated image-based morphing pipeline was used to register corresponding open- and closed-state scans and extract local in-plane strains throughout the leaflet surface at systole. We determined that MI induced