Journal ArticleMechanical Power and Ventilator-induced Lung Injury: What Does Physics Have to Say?Bates, Jason H.T.; Kaczka, David W.; Kollisch-Singule, Michaela; Nieman, Gary F; Gaver III, Donald PVentilator-induced lung injury (VILI) is a potential threat to anyone receiving supportive mechanical ventilation for acute respiratory failure. Despite decades of research, however, the safest way to ventilate any given patient remains controversial. This makes fertile ground for novel concepts, and one that has arisen recently concerns the idea that a ventilator imparts potentially damaging mechanical energy to the lungs. The motivation for this concept is clear: energy transfer is involved when any structure becomes physically damaged. It may be intuitive, then, that the rate at which energy is delivered to the lungs by a ventilator, namely mechanical power, should be associated with VILI. Nevertheless, understanding the relationship between mechanical power and VILI requires clarity on the difference between stored versus dissipated energy regardless of whether ventilation is caused by positive pressure at the airway opening or negative pressure in the pleural space.ATS2023-09-2010472646American Journal of Respiratory and Critical Care Medicine1073-449Xhttps://doi.org/10.1164/rccm.202307-1292VP1706801National Science Foundation