Journal ArticleArtificial intelligence in qualitative analysis: a practical guide and reflections based on results from using GPT to analyze interview data in a substance use programYang, Yang; Ma, LiranLanguage-based text provide valuable insights into people’s lived experiences. While traditional qualitative analysis is used to capture these nuances, new paradigms are needed to scale qualitative research effectively. Artificial intelligence presents an unprecedented opportunity to expand the sale of analysis for obtaining such nuances. The study tests the application of GPT-4—a large language modeling—in qualitative data analysis using an existing set of text data derived from 60 qualitative interviews. Specifically, the study provides a practical guide for social and behavioral researchers, illustrating core elements and key processes, demonstrating its reliability by comparing GPT-generated codes with researchers’ codes, and evaluating its capacity for theory-driven qualitative analysis. The study followed a three-step approach: (1) prompt engineering, (2) reliability assessment by comparison of GPT-generated codes with researchers’ codes, and (3) evaluation of theory-driven thematic analysis on psychological constructs. The study underscores the utility of GPT’s capabilities in coding and analyzing text data with established qualitative methods while highlighting the need for qualitative expertise to guide GPT applications. Recommendations for further exploration are also discussed.Springer Nature2025-02-2610590730Quality & Quantity0033-5177https://doi.org/10.1007/s11135-025-02066-12449011National Science Foundation