- Home
- Search Results
- Page 1 of 1
Search for: All records
-
Total Resources2
- Resource Type
-
00000020000
- More
- Availability
-
20
- Author / Contributor
- Filter by Author / Creator
-
-
Aghabaglou, Fariba (2)
-
Tamayol, Ali (2)
-
Yang, Ruiguo (2)
-
Bonick, Zack (1)
-
Derakhshandeh, Hossein (1)
-
Ghanavati, Ian (1)
-
Harris, Seth (1)
-
Jaberi, Arian (1)
-
Kreikemeier‐Bower, Craig (1)
-
McCarthy, Alec (1)
-
Monemian Esfahani, Amir (1)
-
Moosavi Basri, Seyed Masoud (1)
-
Mostafalu, Pooria (1)
-
Mostafavi, Azadeh (1)
-
Ndao, Sidy (1)
-
Orgill, Dennis (1)
-
Park, Jae Sung (1)
-
Rosenbohm, Jordan (1)
-
Wiseman, Chris (1)
-
#Tyler Phillips, Kenneth E. (0)
-
- Filter by Editor
-
-
& Spizer, S. M. (0)
-
& . Spizer, S. (0)
-
& Ahn, J. (0)
-
& Bateiha, S. (0)
-
& Bosch, N. (0)
-
& Brennan K. (0)
-
& Brennan, K. (0)
-
& Chen, B. (0)
-
& Chen, Bodong (0)
-
& Drown, S. (0)
-
& Ferretti, F. (0)
-
& Higgins, A. (0)
-
& J. Peters (0)
-
& Kali, Y. (0)
-
& Ruiz-Arias, P.M. (0)
-
& S. Spitzer (0)
-
& Sahin. I. (0)
-
& Spitzer, S. (0)
-
& Spitzer, S.M. (0)
-
(submitted - in Review for IEEE ICASSP-2024) (0)
-
-
Have feedback or suggestions for a way to improve these results?
!
Note: When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external site maintained by the publisher.
Some full text articles may not yet be available without a charge during the embargo (administrative interval).
What is a DOI Number?
Some links on this page may take you to non-federal websites. Their policies may differ from this site.
-
Derakhshandeh, Hossein ; Aghabaglou, Fariba ; McCarthy, Alec ; Mostafavi, Azadeh ; Wiseman, Chris ; Bonick, Zack ; Ghanavati, Ian ; Harris, Seth ; Kreikemeier‐Bower, Craig ; Moosavi Basri, Seyed Masoud ; et al ( , Advanced Functional Materials)
Abstract Chronic wounds are one of the most devastating complications of diabetes and are the leading cause of nontraumatic limb amputation. Despite the progress in identifying factors and promising in vitro results for the treatment of chronic wounds, their clinical translation is limited. Given the range of disruptive processes necessary for wound healing, different pharmacological agents are needed at different stages of tissue regeneration. This requires the development of wearable devices that can deliver agents to critical layers of the wound bed in a minimally invasive fashion. Here, for the first time, a programmable platform is engineered that is capable of actively delivering a variety of drugs with independent temporal profiles through miniaturized needles into deeper layers of the wound bed. The delivery of vascular endothelial growth factor (VEGF) through the miniaturized needle arrays demonstrates that, in addition to the selection of suitable therapeutics, the delivery method and their spatial distribution within the wound bed is equally important. Administration of VEGF to chronic dermal wounds of diabetic mice using the programmable platform shows a significant increase in wound closure, re‐epithelialization, angiogenesis, and hair growth when compared to standard topical delivery of therapeutics.