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Passive Remote Sensing services are indispensable in modern society because of the applications related to climate studies and earth science. Among those, NASA’s Soil Moisture Active and Passive (SMAP) mission provides an essential climate variable such as the moisture content of the soil by using microwave radiation within protected band over 1400-1427 MHz. However, because of the increasing active wireless technologies such as Internet of Things (IoT), unmanned aerial vehicles (UAV), and 5G wireless communication, the SMAP’s passive observations are expected to experience an increasing number of Radio Frequency Interference (RFI). RFI is a well-documented issue and SMAP has a ground processing unit dedicated to tackling this issue. However, advanced techniques are needed to tackle the increasing RFI problem for passive sensing systems and to jointly coexist communication and sensing systems. In this paper, we apply a deep learning approach where a novel Convolutional Neural Network (CNN) architecture for both RFI detection and mitigation is employed. SMAP Level 1A spectrogram of antenna counts and various moments data are used as the inputs to the deep learning architecture. We simulate different types of RFI sources such as pulsed, CW or wideband anthropogenic signals. We then use artificially corrupted SMAP Level 1B antenna measurements in conjunction with RFI labels to train the learning architecture. While the learned detection network classifies input spectrograms as RFI or no-RFI cases, the mitigation network reconstructs the RFI mitigated antenna temperature images. The proposed learning framework both takes advantage of the existing SMAP data and the simulated RFI scenarios. Future remote sensing systems such as radiometers will suffer an increasing RFI problem and spectrum sharing and techniques that will allow coexistance of sensing and communication systems will be utmost importance for both parties. RFI detection and mitigation will remain a prerequisite for these radiometers and the proposed deep learning approach has the potential to provide an additional perspective to existing solutions. We will present detailed analysis on the selected deep learning architecture, obtained RFI detection accuracy levels and RFI mitigation performance.