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Zhang, Xueying; Yamada, Yosuke; Sagayama, Hiroyuki; Ainslie, Philip N.; Blaak, Ellen E.; Buchowski, Maciej S.; Close, Graeme L.; Cooper, Jamie A.; Das, Sai Krupa; Dugas, Lara R.; et al (, iScience)
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Westerterp, Klaas R.; Yamada, Yosuke; Sagayama, Hiroyuki; Ainslie, Philip N.; Andersen, Lene F.; Anderson, Liam J.; Arab, Lenore; Baddou, Issaad; Bedu-Addo, Kweku; Blaak, Ellen E.; et al (, The American Journal of Clinical Nutrition)
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Careau, Vincent; Halsey, Lewis G.; Pontzer, Herman; Ainslie, Philip N.; Andersen, Lene F.; Anderson, Liam J.; Arab, Lenore; Baddou, Issad; Bedu-Addo, Kweku; Blaak, Ellen E.; et al (, Current Biology)null (Ed.)
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Speakman, John R.; Yamada, Yosuke; Sagayama, Hiroyuki; Berman, Elena S.F.; Ainslie, Philip N.; Andersen, Lene F.; Anderson, Liam J.; Arab, Lenore; Baddou, Issaad; Bedu-Addo, Kweku; et al (, Cell Reports Medicine)null (Ed.)
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Pontzer, Herman; Yamada, Yosuke; Sagayama, Hiroyuki; Ainslie, Philip N.; Andersen, Lene F.; Anderson, Liam J.; Arab, Lenore; Baddou, Issaad; Bedu-Addo, Kweku; Blaak, Ellen E.; et al (, Science)Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass–adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.more » « less