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Creators/Authors contains: "Asadi, Mojgan"

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  1. ; ( , Journal of the American Chemical Society)
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  2. ; ; ( , Journal of the American Chemical Society)
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  3. ; ; ( , Proceedings of the National Academy of Sciences)
    Although computational enzyme design is of great importance, the advances utilizing physics-based approaches have been slow, and further progress is urgently needed. One promising direction is using machine learning, but such strategies have not been established as effective tools for predicting the catalytic power of enzymes. Here, we show that the statistical energy inferred from homologous sequences with the maximum entropy (MaxEnt) principle significantly correlates with enzyme catalysis and stability at the active site region and the more distant region, respectively. This finding decodes enzyme architecture and offers a connection between enzyme evolution and the physical chemistry of enzyme catalysis, and it deepens our understanding of the stability–activity trade-off hypothesis for enzymes. Overall, the strong correlations found here provide a powerful way of guiding enzyme design. 
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  4. ; ; ( , Journal of the American Chemical Society)
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