The cyclopropyl group is of great importance in medicinal chemistry, as it can be leveraged to influence a range of pharmaceutical properties in drug molecules. This report describes a Vitamin B12‐photocatalyzed approach for the cyclopropanation of electron‐deficient alkenes using dichloromethane (CH2Cl2) as the methylene source. The reaction proceeds in good to excellent yields under mild conditions, has excellent functional group compatibility, and is highly chemoselective. The scope could also be extended to the preparation of D2‐cyclopropyl and methyl‐substituted cyclopropyl adducts starting from CD2Cl2and 1,1‐dichloroethane, respectively.
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Abstract -
Abstract The cyclopropyl group is of great importance in medicinal chemistry, as it can be leveraged to influence a range of pharmaceutical properties in drug molecules. This report describes a Vitamin B12‐photocatalyzed approach for the cyclopropanation of electron‐deficient alkenes using dichloromethane (CH2Cl2) as the methylene source. The reaction proceeds in good to excellent yields under mild conditions, has excellent functional group compatibility, and is highly chemoselective. The scope could also be extended to the preparation of D2‐cyclopropyl and methyl‐substituted cyclopropyl adducts starting from CD2Cl2and 1,1‐dichloroethane, respectively.
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null (Ed.)The title compound, [Cu 2 (C 19 H 23 N 7 O)(C 2 H 3 O 2 ) 4 ] n , was obtained via reaction of copper(II) acetate with the coordinating ligand, 6-ethoxy- N 2 , N 4 -bis[2-(pyridin-2-yl)ethyl]-1,3,5-triazine-2,4-diamine. The crystallized product adopts the monoclinic P 2 1 / c space group. The metal core exhibits a paddle-wheel structure typical for dicopper tetraacetate units, with triazine and pyridyl nitrogen atoms from different ligands coordinating to the two axial positions of the paddle wheel in an asymmetric manner. This forms a coordination polymer with the segments of the polymer created by the c -glide of the P 2 1 / c setting of the space group. The resulting chains running along the c -axis direction are held together by intramolecular N—H...O hydrogen bonding. These chains are further packed by dispersion forces, producing an extended three-dimensional structure.more » « less