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Creators/Authors contains: "Aziz, Marian N."

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  1. ; ; ; ; ; (, European Journal of Medicinal Chemistry)
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  2. ; ; ; ; ; ; (, Molecules)
    An efficient surface-mediated synthetic method to facilitate access to a novel class of thiazolidines is described. The rationale behind the design of the targeted thiazolidines was to prepare stable thiazolidine analogues and evaluate their anti-proliferative activity against a breast cancer cell line (MCF7). Most of the synthesized analogues exhibited increased potency ranging from 2–15-fold higher compared to the standard reference, cisplatin. The most active thiazolidines contain a halogenated or electron withdrawing group attached to the N-phenyl ring of exocyclic 2-imino group. However, combination of the two substituents did not enhance the activity. The anti-proliferative activity was measured in terms of IC50 values using an MTT assay. 
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  3. ; ; ; (, Tetrahedron Letters)
    null (Ed.)
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