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Abstract Aggressive cancers, characterized by high metastatic potential and resistance to conventional therapies, present a significant challenge in oncology. Current treatments often fail to effectively target metastasis, recurrence, and the immunosuppressive tumor microenvironment, while causing significant off‐target toxicity. Here, superparamagnetic copper iron oxide nanoparticles (SCIONs) as a multifunctional platform that integrates magnetic hyperthermia therapy, immune modulation, and targeted chemotherapeutic delivery, aiming to provide a more comprehensive cancer treatment is presented. Specifically, SCIONs generate localized hyperthermia under an alternating magnetic field while delivering a copper‐based anticancer agent, resulting in a synergistic anticancer effect. The hyperthermia induced by SCIONs caused ER stress and ROS production, leading to significant tumor cell death, while the copper complex further enhanced oxidative stress, ferroptosis, and apoptosis. Beyond direct cytotoxicity, SCIONs disrupted the tumor microenvironment by inhibiting cancer‐associated fibroblasts, downregulating epithelial‐mesenchymal transition markers, and reducing cell migration and invasion, thereby limiting metastasis. Additionally, SCION‐based therapy reprogrammed the immune microenvironment by inducing immunogenic cell death and enhancing dendritic cell activation, resulting in increased CD8+ T cell infiltration and amplified antitumor immunity. This integrated approach targets primary and metastatic tumors while mitigating immunosuppression, offering a promising next‐generation therapy for combating cancer with enhanced efficacy and reduced side effects. 

Abstract Axion-like particles (ALPs) are hypothetical particles and compelling candidates for cold dark matter. Their existence could be probed through their conversions into photons in the presence of magnetic fields. In this work, we explore the effect of these photon-ALP conversions by searching for an attenuation in the observed gamma ray spectra of galactic sources that emit at energies of hundreds of TeV. We analyze data from the High-Altitude Water Cherenkov (HAWC) Observatory for the source 3HWC J1908+063. No evidence of photon-ALP conversions was found, and we set constraints on the ALP parameter space. Specifically, we derive exclusion limits for ALPs with masses in the range 10^-8 eV ≤m_a≤ 10^-6 eV and photon-ALP couplings in the range 10^-12 GeV^-1≤g_aγ≤ 10^-10 GeV^-1, based on HAWC observations. 

Abstract We present a new study on the MeV–TeVγ-ray origin of HESS J1857+026 using data collected from the Fermi–LAT, VERITAS, and HAWC observatories. A spatial and spectral study of HESS J1857+026 including radiative modeling of the MeV–TeV spectrum determines the likely dominantγ-ray origin as a pulsar wind nebula (PWN) powered by the energetic pulsar PSR J1856+0245. The MeV–TeV spectrum is further characterized through basic evolutionary radiative modeling assuming a PWN origin to constrain the physical properties of the system such as the magnetic field strength and PWN age. The results of the PWN evolutionary model are consistent with the observational constraints of the system, finding an age of the system betweenτ = [16, 21] kyr and a magnetic field strength betweenB = [0.4, 1.6]μG. These estimates support an evolved PWN scenario where the observedγ-ray emission is generated by the relativistic electrons' inverse Compton (IC) scattering off local photon fields; however, the low-energy (E < 10 GeV) spectral component could be dominated by hadronic emission originating from a supernova remnant (SNR). For a PWN component above 10 GeV, we measure the conditions for particle diffusion, finding that the local diffusion (D(50 TeV) ∼ 10²⁸cm⁻²s⁻¹) is suppressed compared to the interstellar medium (ISM) value, in agreement with similar TeV PWNe. By measuring the radial surface brightness profiles of theγ-ray source across multiple instruments, we demonstrate that the combined MeV–TeV spatial information is a powerful tool to constrain particle diffusion properties. 

Nano-porous aerogels are an advantageous approach to produce low-density materials with high surface area, particularly when using biobased materials. Frequently, most biobased aerogels are synthesized through a bottom-up approach, which requires high energy inputs to break and rebuild the raw materials, and for elimination of water. To curb this, this work focused on generating aerogels by a top-down approach through the delignification of a wood substrate while eliminating water by solvent exchange. To diversify the surface chemistry for use in water treatment, the delignified wood–nanowood-was coated with a chitosan–cyclodextrin co-polymer and tested in the capture of microcystin-LR. The generated nanowood structure had 75% porosity after coating, with up to 339% water swelling and an adsorption capacity of 0.12 mg g −1 of the microcystin. This top-down technique enables the generation of low-cost aerogels by reducing steps, using a biobased self-assembled coating with hydrophobic active sites, and avoiding costly energetic input. 

Titanium nitride (TiN) materials have gained an interest over the past years due to their unique characteristics, such as thermal stability, extreme hardness, low production cost, and comparable optical properties to gold. In the present study, TiN nanoparticles were synthesized via a thermal benzene route to obtain black nanoparticles. Scanning electron microscopy (SEM) was carried out to examine the morphology. Further microscopic characterization was done where the final product was drop cast onto double-sided conductive carbon tape and sputter-coated with gold/palladium at a thickness of 4 nm for characterization by field emission scanning electron microscopy (FE-SEM) with energy dispersive X-Ray spectroscopy (EDS) that revealed they are spherical. ImageJ software was used to measure the average size of the particles to be 79 nm in diameter. EDS was used to determine the elements present in the sample and concluded that there were no impurities. Further characterization by Fourier Transform infrared (FTIR) spectroscopy was carried out to identify the characteristic peaks of TiN. X-ray diffraction (XRD) revealed typical peaks of cubic phase titanium nitride, and crystallite size was determined to be 14 nm using the Debye-Scherrer method. Dynamic light scattering (DLS) analysis revealed the size distribution of the TiN nanoparticles, with nanoparticles averaging at 154 nm in diameter. Zeta potential concluded the surface of the TiN nanoparticles is negatively charged.