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We propose a survival analysis approach for discovering and characterizing user behavior and risks for lending protocols in decentralized finance (DeFi). We demonstrate how to gather and prepare DeFi transaction data for survival analysis. We illustrate our approach using transactions in Aave, one of the largest lending protocols. We develop a DeFi survival analysis pipeline that first prepares transaction data for survival analysis through the selection of different index events (or transactions) and associated outcome events. Then we apply survival analysis statistical and visualization methods modified for competing risks when appropriate, such as Kaplan–Meier survival curves, cumulative incidence functions, Cox hazard regression, and Fine-Gray models for sub-distribution hazards to gain insights into usage patterns and risks within the protocol. We show how, by varying the index and outcome events as well as covariates, we can use DeFi survival analysis to answer questions like “How does loan size affect the repayment schedule of the loan?”; “How does loan size affect the likelihood that an account gets liquidated?”; “How does user behavior vary between Aave markets?”; “How has user behavior in Aave varied from quarter to quarter?” The proposed DeFi survival analysis can easily be generalized to other DeFi lending protocols. By defining appropriate index and outcome events, DeFi survival analysis can be applied to any cryptocurrency protocol with transactions. 

The emerging decentralized financial ecosystem (DeFi) is comprised of numerous protocols, one type being lending protocols. People make transactions in lending protocols, each of which is attributed to a specific blockchain address which could represent an externally-owned account (EOA) or a smart contract. Using Aave, one of the largest lending protocols, we summarize the transactions made by each address in each quarter from January 1, 2021, through December 31, 2022. We cluster these quarterly summaries to identify and name common patterns of quarterly behavior in Aave. We then use these clusters to glean insights into the dominant behaviors in Aave. We show that there are three kinds of keepers, i.e., a specific type of users tasked with the protocol’s governance, but only one kind of keeper finds consistent success in making profits from liquidations. We identify the largest-scale accounts in Aave and the highest-risk kinds of behavior on the platform. Additionally, we use the temporal aspect of the clusters to track how common behaviors change through time and how usage has shifted in the wake of major events that impacted the crypto market, and we show that there seem to be problems with user retention in Aave as many of the addresses that perform transactions do not remain in the market for long. 

Streams of irregularly occurring events are commonly modeled as a marked temporal point process. Many real-world datasets such as e-commerce transactions and electronic health records often involve events where multiple event types co-occur, e.g. multiple items purchased or multiple diseases diagnosed simultaneously. In this paper, we tackle multi-label prediction in such a problem setting, and propose a novel Transformer-based Conditional Mixture of Bernoulli Network (TCMBN) that leverages neural density estimation to capture complex temporal dependence as well as probabilistic dependence between concurrent event types. We also propose potentially incorporating domain knowledge in the objective by regularizing the predicted probability. To represent probabilistic dependence of concurrent event types graphically, we design a two-step approach that first learns the mixture of Bernoulli network and then solves a least-squares semi-definite constrained program to numerically approximate the sparse precision matrix from a learned covariance matrix. This approach proves to be effective for event prediction while also providing an interpretable and possibly non-stationary structure for insights into event co-occurrence. We demonstrate the superior performance of our approach compared to existing baselines on multiple synthetic and real benchmarks. 

We propose a decentralized finance (DeFi) survival analysis approach for discovering and characterizing user behavior and risks in lending protocols. We demonstrate how to gather and prepare DeFi transaction data for survival analysis. We demonstrate our approach using transactions in AAVE, one of the largest lending protocols. We develop a DeFi survival analysis pipeline which first prepares transaction data for survival analysis through the selection of different index events (or transactions) and associated outcome events. Then we apply survival analysis statistical and visualization methods such as median survival times, Kaplan–Meier survival curves, and Cox hazard regression to gain insights into usage patterns and risks within the protocol. We show how by varying the index and outcome events, we can utilize DeFi survival analysis to answer three different questions. What do users do after a deposit? How long until borrows are first repaid or liquidated? How does coin type influence liquidation risk? The proposed DeFi survival analysis can easily be generalized to other DeFi lending protocols. By defining appropriate index and outcome events, DeFi survival analysis can be applied to any cryptocurrency protocol with transactions. 

Abstract Circadian rhythms broadly regulate physiological functions by tuning oscillations in the levels of mRNAs and proteins to the 24-h day/night cycle. Globally assessing which mRNAs and proteins are timed by the clock necessitates accurate recognition of oscillations in RNA and protein data, particularly in large omics data sets. Tools that employ fixed-amplitude models have previously been used to positive effect. However, the recognition of amplitude change in circadian oscillations required a new generation of analytical software to enhance the identification of these oscillations. To address this gap, we created the Pipeline for Amplitude Integration of Circadian Exploration suite. Here, we demonstrate the Pipeline for Amplitude Integration of Circadian Exploration suite’s increased utility to detect circadian trends through the joint modeling of the Mus musculus macrophage transcriptome and proteome. Our enhanced detection confirmed extensive circadian posttranscriptional regulation in macrophages but highlighted that some of the reported discrepancy between mRNA and protein oscillations was due to noise in data. We further applied the Pipeline for Amplitude Integration of Circadian Exploration suite to investigate the circadian timing of noncoding RNAs, documenting extensive circadian timing of long noncoding RNAs and small nuclear RNAs, which control the recognition of mRNA in the spliceosome complex. By tracking oscillating spliceosome complex proteins using the PAICE suite, we noted that the clock broadly regulates the spliceosome, particularly the major spliceosome complex. As most of the above-noted rhythms had damped amplitude changes in their oscillations, this work highlights the importance of the PAICE suite in the thorough enumeration of oscillations in omics-scale datasets.