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  1. A connectivity graph of neurons at the resolution of single synapses provides scientists with a tool for understanding the nervous system in health and disease. Recent advances in automatic image segmentation and synapse prediction in electron microscopy (EM) datasets of the brain have made reconstructions of neurons possible at the nanometer scale. However, automatic segmentation sometimes struggles to segment large neurons correctly, requiring human effort to proofread its output. General proofreading involves inspecting large volumes to correct segmentation errors at the pixel level, a visually intensive and time-consuming process. This paper presents the design and implementation of an analytics frameworkmore »that streamlines proofreading, focusing on connectivity-related errors. We accomplish this with automated likely-error detection and synapse clustering that drives the proofreading effort with highly interactive 3D visualizations. In particular, our strategy centers on proofreading the local circuit of a single cell to ensure a basic level of completeness. We demonstrate our framework’s utility with a user study and report quantitative and subjective feedback from our users. Overall, users find the framework more efficient for proofreading, understanding evolving graphs, and sharing error correction strategies.« less
  2. Free, publicly-accessible full text available November 1, 2022
  3. A correction to this paper has been published: 10.1140/epjc/s10052-021-09344-w
    Free, publicly-accessible full text available October 1, 2022
  4. Abstract This paper presents a search for dark matter in the context of a two-Higgs-doublet model together with an additional pseudoscalar mediator, a , which decays into the dark-matter particles. Processes where the pseudoscalar mediator is produced in association with a single top quark in the 2HDM+ a model are explored for the first time at the LHC. Several final states which include either one or two charged leptons (electrons or muons) and a significant amount of missing transverse momentum are considered. The analysis is based on proton–proton collision data collected with the ATLAS experiment at $$\sqrt{s} = 13$$ smore »= 13  TeV during LHC Run 2 (2015–2018), corresponding to an integrated luminosity of 139  $$\hbox {fb}^{-1}$$ fb - 1 . No significant excess above the Standard Model predictions is found. The results are expressed as 95% confidence-level limits on the parameters of the signal models considered.« less
    Free, publicly-accessible full text available October 1, 2022
  5. Abstract Jet energy scale and resolution measurements with their associated uncertainties are reported for jets using 36–81 fb $$^{-1}$$ - 1 of proton–proton collision data with a centre-of-mass energy of $$\sqrt{s}=13$$ s = 13   $${\text {Te}}{\text {V}}$$ TeV collected by the ATLAS detector at the LHC. Jets are reconstructed using two different input types: topo-clusters formed from energy deposits in calorimeter cells, as well as an algorithmic combination of charged-particle tracks with those topo-clusters, referred to as the ATLAS particle-flow reconstruction method. The anti- $$k_t$$ k t jet algorithm with radius parameter $$R=0.4$$ R = 0.4 is the primary jetmore »definition used for both jet types. This result presents new jet energy scale and resolution measurements in the high pile-up conditions of late LHC Run 2 as well as a full calibration of particle-flow jets in ATLAS. Jets are initially calibrated using a sequence of simulation-based corrections. Next, several in situ techniques are employed to correct for differences between data and simulation and to measure the resolution of jets. The systematic uncertainties in the jet energy scale for central jets ( $$|\eta |<1.2$$ | η | < 1.2 ) vary from 1% for a wide range of high- $$p_{{\text {T}}}$$ p T jets ( $$2502.5~{\text {Te}}{\text {V}}$$ > 2.5 TeV ). The relative jet energy resolution is measured and ranges from ( $$24 \pm 1.5$$ 24 ± 1.5 )% at 20  $${\text {Ge}}{\text {V}}$$ GeV to ( $$6 \pm 0.5$$ 6 ± 0.5 )% at 300  $${\text {Ge}}{\text {V}}$$ GeV .« less
  6. Abstract The production cross-section of a top quark in association with a W boson is measured using proton–proton collisions at $$\sqrt{s} = 8\,\text {TeV}$$ s = 8 TeV . The dataset corresponds to an integrated luminosity of $$20.2\,\text {fb}^{-1}$$ 20.2 fb - 1 , and was collected in 2012 by the ATLAS detector at the Large Hadron Collider at CERN. The analysis is performed in the single-lepton channel. Events are selected by requiring one isolated lepton (electron or muon) and at least three jets. A neural network is trained to separate the tW signal from the dominant $$t{\bar{t}}$$ t tmore »¯ background. The cross-section is extracted from a binned profile maximum-likelihood fit to a two-dimensional discriminant built from the neural-network output and the invariant mass of the hadronically decaying W boson. The measured cross-section is $$\sigma _{tW} = 26 \pm 7\,\text {pb}$$ σ tW = 26 ± 7 pb , in good agreement with the Standard Model expectation.« less
  7. Abstract The results of a search for gluino and squark pair production with the pairs decaying via the lightest charginos into a final state consisting of two W bosons, the lightest neutralinos ( $$\tilde{\chi }^0_1$$ χ ~ 1 0 ), and quarks, are presented: the signal is characterised by the presence of a single charged lepton ( $$e^{\pm }$$ e ± or $$\mu ^{\pm }$$ μ ± ) from a W boson decay, jets, and missing transverse momentum. The analysis is performed using 139 fb $$^{-1}$$ - 1 of proton–proton collision data taken at a centre-of-mass energy $$\sqrt{s}=13$$ s = 13more »  delivered by the Large Hadron Collider and recorded by the ATLAS experiment. No statistically significant excess of events above the Standard Model expectation is found. Limits are set on the direct production of squarks and gluinos in simplified models. Masses of gluino (squark) up to 2.2  (1.4 ) are excluded at 95% confidence level for a light $$\tilde{\chi }^0_1$$ χ ~ 1 0 .« less