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Pausch, Patrick ; Al-Shayeb, Basem ; Bisom-Rapp, Ezra ; Tsuchida, Connor A. ; Li, Zheng ; Cress, Brady F. ; Knott, Gavin J. ; Jacobsen, Steven E. ; Banfield, Jillian F. ; Doudna, Jennifer A. ( , Science)
CRISPR-Cas systems are found widely in prokaryotes, where they provide adaptive immunity against virus infection and plasmid transformation. We describe a minimal functional CRISPR-Cas system, comprising a single ~70-kilodalton protein, CasΦ, and a CRISPR array, encoded exclusively in the genomes of huge bacteriophages. CasΦ uses a single active site for both CRISPR RNA (crRNA) processing and crRNA-guided DNA cutting to target foreign nucleic acids. This hypercompact system is active in vitro and in human and plant cells with expanded target recognition capabilities relative to other CRISPR-Cas proteins. Useful for genome editing and DNA detection but with a molecular weight half that of Cas9 and Cas12a genome-editing enzymes, CasΦ offers advantages for cellular delivery that expand the genome editing toolbox.
