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Abstract Planar magnetic microswimmers offer substantial potential for in vivo biomedical applications, owing to their efficient mass production via photolithography. In this study, we demonstrate the effective control of these microswimmers using an open-loop approach in environments with minimal external disturbances. We investigate their surface motion characteristics through both theoretical modeling and experimental testing under varying magnetic field strengths and rotation frequencies, identifying regions of stable and unstable motion. Additionally, we analyze how field frequency and strength influence surface motion speed and identify the frequencies that promote stability. Open-loop control of surface motion in fluid environments and swimming in channels is also demonstrated, highlighting the operational flexibility of these microswimmers. We further demonstrate swarm motion for both swimming and surface operations, exhibiting larger-scale coordination. Our findings emphasize their potential for future applications in biomedical engineering and microrobotics, marking a step forward in the development of microscale robotic systems. 

Planar magnetic microswimmers bear great potential for in vivo biomedical applications as they can be mass‐produced at minimal costs using standard photolithography techniques. Therefore, it is central to understand how to control their motion. This study examines the propulsion of planar V‐shaped microswimmers in an aqueous solution powered by a conically rotating magnetic field and compares the experimental results with theory. Propulsion is investigated upon altering the cone angle of the driving field. It is shown that a V‐shaped microswimmer magnetized along its symmetry axis exhibits unidirectional in‐sync propulsion with a constant (frequency‐independent) velocity in a limited band of actuation frequencies. It is also demonstrated that the motion of individual and multiple in‐plane magnetized planar microswimmers in a conically rotating field can be efficiently controlled. 

Over the past two decades, there has been a growing body of work on wireless devices that can operate on the length scales of biological cells and even smaller. A class of these devices receiving increasing attention are referred to as bio-hybrid actuators: tools that integrate biological cells or subcellular parts with synthetic or inorganic components. These devices are commonly controlled through magnetic manipulation as magnetic fields and gradients can be generated with a high level of control. Recent work has demonstrated that magnetic bio-hybrid actuators can address common challenges in small scale fabrication, control, and localization. Additionally, it is becoming apparent that these magnetically driven bio-hybrid devices can display high efficiency and, in many cases, have the potential for self-repair and even self-replication. Combining these properties with magnetically driven forces and torques, which can be transmitted over significant distances, can be highly controlled, and are biologically safe, gives magnetic bio-hybrid actuators significant advantages over other classes of small scale actuators. In this review, we describe the theory and mechanisms required for magnetic actuation, classify bio-hybrid actuators by their diverse organic components, and discuss their current limitations. Insights into the future of coupling cells and cell-derived components with magnetic materials to fabricate multi-functional actuators are also provided. 

Abstract Magnetic achiral planar microswimmers can be massively fabricated at low cost and are envisioned to be useful for in vivo biomedical applications. To understand locomotion in representative in vivo environments, we investigated the swimming performance of achiral planar microswimmers in methylcellulose solutions. We observed that these microswimmers displayed very similar swimming characteristics in methylcellulose solutions as in water. Furthermore, this study indicated that the range of precession angles increased as the concentration of MC solution increased. Last, it was demonstrated that achiral planar microswimmers with similar precession angles exhibited nearly the same dimensionless speeds in different concentrations of the methylcellulose solutions. Upon understanding swimmer kinematics, more effective control over the achiral planar microswimmers can be achieved to perform multiple biomedical tasks in in vivo environments.