Search for: All records | NSF Public Access

Note: When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external site maintained by the publisher. Some full text articles may not yet be available without a charge during the embargo (administrative interval).
What is a DOI Number?

Some links on this page may take you to non-federal websites. Their policies may differ from this site.

Learning to reason about contextual knowledge for planning under uncertainty

Cui, Cheng ; Amiri, Saeid ; Ding, Yan ; Zhan, Xingyue ; Zhang, Shiqi ( August 2023 , Proceedings of the Thirty-Ninth Conference on Uncertainty in Artificial Intelligence)
Learning to reason about contextual knowledge for planning under uncertainty

Cui, Cheng ; Amiri, Saeid ; Ding, Yan ; Zhan, Xingyue ; Zhang, Shiqi ( July 2023 , UAI '23: Proceedings of the Thirty-Ninth Conference on Uncertainty in Artificial Intelligence)
Enhanced Targeted Gene Transduction: AAV2 Vectors Conjugated to Multiple Aptamers via Reducible Disulfide Linkages

https://doi.org/10.1021/jacs.7b08518

Wu, Yuan ; Zhang, Liqin ; Cui, Cheng ; Cansiz, Sena ; Liang, Hao ; Wu, Cuichen ; Teng, I-Ting ; Chen, Weijun ; Liu, Yuan ; Hou, Weijia ; et al ( December 2017 , Journal of the American Chemical Society)

Full Text Available
Enhancing the Nucleolytic Resistance and Bioactivity of Functional Nucleic Acids by Diverse Nanostructures through in Situ Polymerization‐Induced Self‐assembly

https://doi.org/10.1002/cbic.202000712

Yang, Lu ; Liang, Mingwei ; Cui, Cheng ; Li, Xiaowei ; Li, Long ; Pan, Xiaoshu ; Yazd, Hoda Safari ; Hong, Min ; Lu, Jianrong ; Cao, Y. Charles ; et al ( December 2020 , ChemBioChem)

Abstract
Functional nucleic acids (FNAs) are garnering tremendous interest owing to their high modularity and unique bioactivity. Three‐dimensional FNAs have been developed to overcome the issues of nuclease degradation and limited cell uptake. We have developed a new facile approach to the synthesis of multiple three‐dimensional FNA nanostructures by harnessing photo‐polymerization‐induced self‐assembly. Sgc8 aptamer and CpG oligonucleotide were modified as macro chain‐transfer reagents to mediate in situ polymerization and self‐assembly. Diverse structures, including micelles, rods, and short worms, afford these two FNAs afford these two FNAs with higher nuclease resistance in serum serum, greater cellular uptake efficiency, and increased bioactivity.

more » « less