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Abstract Human cerebellum consists of high density and complexity of neurons. Thus, it is challenging to differentiate cerebellar-like organoids with similar cellular markers and function to the human brain. Our previous study showed that the combination of retinoic acid (RA), Wingless/integrated (Wnt) activator, and Sonic Hedgehog (SHH) activator promotes cerebellar differentiation from human induced pluripotent stem cells (hiPSCs). This study examined phenotypic, metabolic, and biogenesis in early cerebellar development. Cerebellum spheroids were differentiated from human iPSK3 cells. During day 7–14, RA and Wnt activator CHIR99021 were used and SHH activator purmorphamine (PMR) was added later to promote ventralization. Gene expressionmore »Free, publicly-accessible full text available December 1, 2023
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This study assesses physical and chemical properties of fiber reinforced polymer (FRP) composite materials aged in Alaska’s subarctic climate. Carbon FRP (CFRP) and glass FRP (GFRP) samples were collected in 2019 from the exterior and interior of Ted Stevens International Airport (TSIA, retrofitted in 2008) and McKinley Tower (MKT, retrofitted in 2004). Differential scanning calorimetry (DSC) was used to measure glass transition temperature (Tg) and physical aging, FTIR and Raman spectroscopy were used to investigate potential chemical degradation and degree of cure, and scanning electron microscopy (SEM) to evaluate cross-sectional microstructure, respectively. The results indicate that exposure to the subarcticmore »Free, publicly-accessible full text available July 18, 2023
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Free, publicly-accessible full text available June 1, 2023
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Dolgov, Andrey (Ed.)Abstract The phenology, distribution, and size composition of plankton communities are changing rapidly in response to warming. This may lead to shifts in the prey fields of planktivorous fish, which play a key role in transferring energy up marine food chains. Here, we use 60 + years of Continuous Plankton Recorder data to explore temporal trends in key taxa and community traits in the prey field of planktivorous lesser sandeels (Ammodytes marinus) in the North Sea, the Faroes and southern Iceland. We found marked spatial variation in the prey field, with Calanus copepods generally being much more common in the northern partmore »Free, publicly-accessible full text available June 11, 2023
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Abstract The Arctic seasonal halocline impacts the exchange of heat, energy, and nutrients between the surface and the deeper ocean, and it is changing in response to Arctic sea ice melt over the past several decades. Here, we assess seasonal halocline formation in 1975 and 2006–12 by comparing daily, May–September, salinity profiles collected in the Canada Basin under sea ice. We evaluate differences between the two time periods using a one-dimensional (1D) bulk model to quantify differences in freshwater input and vertical mixing. The 1D metrics indicate that two separate factors contribute similarly to stronger stratification in 2006–12 relative tomore »Free, publicly-accessible full text available July 1, 2023
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Free, publicly-accessible full text available June 1, 2023
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In the k -cut problem, we want to find the lowest-weight set of edges whose deletion breaks a given (multi)graph into k connected components. Algorithms of Karger and Stein can solve this in roughly O ( n 2k ) time. However, lower bounds from conjectures about the k -clique problem imply that Ω ( n (1- o (1)) k ) time is likely needed. Recent results of Gupta, Lee, and Li have given new algorithms for general k -cut in n 1.98k + O(1) time, as well as specialized algorithms with better performance for certain classes of graphs (e.g., formore »Free, publicly-accessible full text available February 28, 2023
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Free, publicly-accessible full text available March 1, 2023
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Free, publicly-accessible full text available February 28, 2023
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Free, publicly-accessible full text available March 1, 2023