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Abstract The brain lacks a conventional lymphatic system to remove metabolic waste. It has been proposed that directional fluid movement through the arteriolar paravascular space (PVS) promotes metabolite clearance. We performed simulations to examine if arteriolar pulsations and dilations can drive directional CSF flow in the PVS and found that arteriolar wall movements do not drive directional CSF flow. We propose an alternative method of metabolite clearance from the PVS, namely fluid exchange between the PVS and the subarachnoid space (SAS). In simulations with compliant brain tissue, arteriolar pulsations did not drive appreciable fluid exchange between the PVS and the SAS. However, when the arteriole dilated, as seen during functional hyperemia, there was a marked exchange of fluid. Simulations suggest that functional hyperemia may serve to increase metabolite clearance from the PVS. We measured blood vessels and brain tissue displacement simultaneously in awake, head-fixed mice using two-photon microscopy. These measurements showed that brain deforms in response to pressure changes in PVS, consistent with our simulations. Our results show that the deformability of the brain tissue needs to be accounted for when studying fluid flow and metabolite transport. 

Cerebrospinal fluid (CSF) flows through the brain, transporting chemical signals and removing waste. CSF production in the brain is balanced by a constant outflow of CSF, the anatomical basis of which is poorly understood. Here, we characterized the anatomy and physiological function of the CSF outflow pathway along the olfactory sensory nerves through the cribriform plate, and into the nasal epithelia. Chemical ablation of olfactory sensory nerves greatly reduced outflow of CSF through the cribriform plate. The reduction in CSF outflow did not cause an increase in intracranial pressure (ICP), consistent with an alteration in the pattern of CSF drainage or production. Our results suggest that damage to olfactory sensory neurons (such as from air pollution) could contribute to altered CSF turnover and flow, providing a potential mechanism for neurological diseases. 

Abstract The 2 mm Mapping Obscuration to Reionization with ALMA (MORA) Survey was designed to detect high-redshift ( z ≳ 4), massive, dusty star-forming galaxies (DSFGs). Here we present two likely high-redshift sources, identified in the survey, whose physical characteristics are consistent with a class of optical/near-infrared (OIR)-invisible DSFGs found elsewhere in the literature. We first perform a rigorous analysis of all available photometric data to fit spectral energy distributions and estimate redshifts before deriving physical properties based on our findings. Our results suggest the two galaxies, called MORA-5 and MORA-9, represent two extremes of the “OIR-dark” class of DSFGs. MORA-5 ( z phot = 4.3 − 1.3 + 1.5 ) is a significantly more active starburst with a star formation rate (SFR) of 830 − 190 + 340 M ⊙ yr −1 compared to MORA-9 ( z phot = 4.3 − 1.0 + 1.3 ), whose SFR is a modest 200 − 60 + 250 M ⊙ yr −1 . Based on the stellar masses ( M ⋆ ≈ 10 10−11 M ⊙ ), space density ( n ∼ (5 ± 2) × 10 −6 Mpc −3 , which incorporates two other spectroscopically confirmed OIR-dark DSFGs in the MORA sample at z = 4.6 and z = 5.9), and gas depletion timescales (<1 Gyr) of these sources, we find evidence supporting the theory that OIR-dark DSFGs are the progenitors of recently discovered 3 < z < 4 massive quiescent galaxies. 

ABSTRACT We present optical and near-infrared imaging covering a ∼1.53 deg2 region in the Super-Cluster Assisted Shear Survey (SuperCLASS) field, which aims to make the first robust weak lensing measurement at radio wavelengths. We derive photometric redshifts for ≈176 000 sources down to $$i^\prime _{\rm AB}\sim 24$$ and present photometric redshifts for 1.4 GHz expanded Multi-Element Radio Linked Interferometer Network (e-MERLIN) and Karl G. Jansky Very Large Array (VLA) detected radio sources found in the central 0.26 deg2. We compile an initial catalogue of 149 radio sources brighter than S1.4 > 75 μJy and find their photometric redshifts span 0 < zphot < 4 with radio luminosities between 1021 and 1025 W Hz−1, with medians of $$\langle z \rangle \, =0.55$$ and $$\langle L_{1.4}\rangle \, =1.9\times 10^{23}$$ W Hz−1, respectively. We find 95 per cent of the μJy radio source sample (141/149) have spectral energy distributions (SEDs) best fit by star-forming templates while 5 per cent (8/149) are better fit by active galactic nuclei (AGN). Spectral indices are calculated for sources with radio observations from the VLA and Giant Metrewave Radio Telescope (GMRT) at 325 MHz, with an average spectral slope of α = 0.59 ± 0.04. Using the full photometric redshift catalogue, we construct a density map at the redshift of the known galaxy clusters, z = 0.20 ± 0.08. Four of the five clusters are prominently detected at $$\gt 7\, \sigma$$ in the density map and we confirm the photometric redshifts are consistent with previously measured spectra from a few galaxies at the cluster centres. 

Abstract We present the characteristics of 2 mm selected sources from the largest Atacama Large Millimeter/submillimeter Array (ALMA) blank-field contiguous survey conducted to date, the Mapping Obscuration to Reionization with ALMA (MORA) survey covering 184 arcmin²at 2 mm. Twelve of 13 detections above 5σare attributed to emission from galaxies, 11 of which are dominated by cold dust emission. These sources have a median redshift of $〈z_{2\mathrm{mm}}〉={3.6}_{-0.3}^{+0.4}$primarily based on optical/near-infrared photometric redshifts with some spectroscopic redshifts, with 77% ± 11% of sources atz> 3 and 38% ± 12% of sources atz> 4. This implies that 2 mm selection is an efficient method for identifying the highest-redshift dusty star-forming galaxies (DSFGs). Lower-redshift DSFGs (z< 3) are far more numerous than those atz> 3 yet are likely to drop out at 2 mm. MORA shows that DSFGs with star formation rates in excess of 300M_⊙yr⁻¹and a relative rarity of ∼10⁻⁵Mpc⁻³contribute ∼30% to the integrated star formation rate density at 3 <z< 6. The volume density of 2 mm selected DSFGs is consistent with predictions from some cosmological simulations and is similar to the volume density of their hypothesized descendants: massive, quiescent galaxies atz> 2. Analysis of MORA sources’ spectral energy distributions hint at steeper empirically measured dust emissivity indices than reported in typical literature studies, with $〈\beta 〉={2.2}_{-0.4}^{+0.5}$. The MORA survey represents an important step in taking census of obscured star formation in the universe’s first few billion years, but larger area 2 mm surveys are needed to more fully characterize this rare population and push to the detection of the universe’s first dusty galaxies.