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Abstract Organic electronics can be biocompatible and conformable, enhancing the ability to interface with tissue. However, the limitations of speed and integration have, thus far, necessitated reliance on silicon-based technologies for advanced processing, data transmission and device powering. Here we create a stand-alone, conformable, fully organic bioelectronic device capable of realizing these functions. This device, vertical internal ion-gated organic electrochemical transistor (vIGT), is based on a transistor architecture that incorporates a vertical channel and a miniaturized hydration access conduit to enable megahertz-signal-range operation within densely packed integrated arrays in the absence of crosstalk. These transistors demonstrated long-term stability in physiologic media, and were used to generate high-performance integrated circuits. We leveraged the high-speed and low-voltage operation of vertical internal ion-gated organic electrochemical transistors to develop alternating-current-powered conformable circuitry to acquire and wirelessly communicate signals. The resultant stand-alone device was implanted in freely moving rodents to acquire, process and transmit neurophysiologic brain signals. Such fully organic devices have the potential to expand the utility and accessibility of bioelectronics to a wide range of clinical and societal applications. 

Observed scatter in the Lyαopacity of quasar sightlines atz< 6 has motivated measurements of the correlation between Lyαopacity and galaxy density, as models that predict this scatter make strong and sometimes opposite predictions for how they should be related. Our previous work associated two highly opaque Lyαtroughs atz∼ 5.7 with a deficit of Lyαemitting galaxies (LAEs). In this work, we survey two of the most highly transmissive lines of sight at this redshift toward thez= 6.02 quasar SDSS J1306+0356 and thez= 6.17 quasar PSO J359-06. We find that both fields are underdense in LAEs within 10h⁻¹Mpc of the quasar sightline, somewhat less extensive than underdensities associated with Lyαtroughs. We combine our observations with three additional fields from the literature and find that while fields with extreme opacities are generally underdense, moderate opacities span a wider density range. The results at high opacities are consistent with models that invoke UV background fluctuations and/or late reionization to explain the observed scatter in intergalactic medium (IGM) Lyαopacities. There is tension at low opacities, however, as the models tend to associate lower IGM Lyαopacities with higher densities. Although the number of fields surveyed is still small, the low-opacity results may support a scenario in which the ionizing background in low-density regions increases more rapidly than some models suggest after becoming ionized. Elevated gas temperatures from recent reionization may also be making these regions more transparent.

 

Abstract The first stars were born from chemically pristine gas. They were likely massive, and thus they rapidly exploded as supernovae, enriching the surrounding gas with the first heavy elements. In the Local Group, the chemical signatures of the first stellar population were identified among low-mass, long-lived, very metal-poor ([Fe/H] < −2) stars, characterized by high abundances of carbon over iron ([C/Fe] > +0.7): the so-called carbon-enhanced metal-poor stars. Conversely, a similar carbon excess caused by first-star pollution was not found in dense neutral gas traced by absorption systems at different cosmic time. Here we present the detection of 14 very metal-poor, optically thick absorbers at redshift z ∼ 3–4. Among these, 3 are carbon-enhanced and reveal an overabundance with respect to Fe of all the analyzed chemical elements (O, Mg, Al, and Si). Their relative abundances show a distribution with respect to [Fe/H] that is in very good agreement with those observed in nearby very metal-poor stars. All the tests we performed support the idea that these C-rich absorbers preserve the chemical yields of the first stars. Our new findings suggest that the first-star signatures can survive in optically thick but relatively diffuse absorbers, which are not sufficiently dense to sustain star formation and hence are not dominated by the chemical products of normal stars. 

Deoxyribonucleic acid (DNA) is emerging as an alternative archival memory technology. Recent advancements in DNA synthesis and sequencing have both increased the capacity and decreased the cost of storing information in de novo synthesized DNA pools. In this survey, we review methods for translating digital data to and/or from DNA molecules. An emphasis is placed on methods which have been validated by storing and retrieving real-world data via in-vitro experiments.

 

Advances in time-resolved structural techniques, mainly in macromolecular crystallography and small-angle X-ray scattering (SAXS), allow for a detailed view of the dynamics of biological macromolecules and reactions between binding partners. Of particular promise, are mix-and-inject techniques, which offer a wide range of experimental possibility as microfluidic mixers are used to rapidly combine two species just prior to data collection. Most mix-and-inject approaches rely on diffusive mixers, which have been effectively used within crystallography and SAXS for a variety of systems, but their success is dependent on a specific set of conditions to facilitate fast diffusion for mixing. The use of a new chaotic advection mixer designed for microfluidic applications helps to further broaden the types of systems compatible with time-resolved mixing experiments. The chaotic advection mixer can create ultra-thin, alternating layers of liquid, enabling faster diffusion so that even more slowly diffusing molecules, like proteins or nucleic acids, can achieve fast mixing on timescales relevant to biological reactions. This mixer was first used in UV–vis absorbance and SAXS experiments with systems of a variety of molecular weights, and thus diffusion speeds. Careful effort was also dedicated to making a loop-loading sample-delivery system that consumes as little sample as possible, enabling the study of precious, laboratory-purified samples. The combination of the versatile mixer with low sample consumption opens the door to many new applications for mix-and-inject studies. 

We measure the mean free path ($\lambda _{\rm mfp,H\, \small {I}}$), photoionization rate ($\langle \Gamma _{\rm H\, \small {I}} \rangle$), and neutral fraction ($\langle f_{\rm H\, \small {I}} \rangle$) of hydrogen in 12 redshift bins at 4.85 < z < 6.05 from a large sample of moderate resolution XShooter and ESI QSO absorption spectra. The fluctuations in ionizing radiation field are modelled by post-processing simulations from the Sherwood suite using our new code ‘EXtended reionization based on the Code for Ionization and Temperature Evolution’ (ex-cite). ex-cite uses efficient Octree summation for computing intergalactic medium attenuation and can generate large number of high resolution $\Gamma _{\rm H\, \small {I}}$ fluctuation models. Our simulation with ex-cite shows remarkable agreement with simulations performed with the radiative transfer code Aton and can recover the simulated parameters within 1σ uncertainty. We measure the three parameters by forward-modelling the  Lyα forest and comparing the effective optical depth ($\tau _{\rm eff, H\, \small {I}}$) distribution in simulations and observations. The final uncertainties in our measured parameters account for the uncertainties due to thermal parameters, modelling parameters, observational systematics, and cosmic variance. Our best-fitting parameters show significant evolution with redshift such that $\lambda _{\rm mfp,H\, \small {I}}$ and $\langle f_{\rm H\, \small {I}} \rangle$ decreases and increases by a factor ∼6 and ∼104, respectively from z ∼ 5 to z ∼ 6. By comparing our $\lambda _{\rm mfp,H\, \small {I}}$, $\langle \Gamma _{\rm H\, \small {I}} \rangle$ and $\langle f_{\rm H\, \small {I}} \rangle$ evolution with that in state-of-the-art Aton radiative transfer simulations and the Thesan and CoDa-III simulations, we find that our best-fitting parameter evolution is consistent with a model in which reionization completes by z ∼ 5.2. Our best-fitting model that matches the $\tau _{\rm eff, H\, \small {I}}$ distribution also reproduces the dark gap length distribution and transmission spike height distribution suggesting robustness and accuracy of our measured parameters.

 

The mean free path of ionizing photons,λ_mfp, is a critical parameter for modeling the intergalactic medium (IGM) both during and after reionization. We present direct measurements ofλ_mfpfrom QSO spectra over the redshift range 5 <z< 6, including the first measurements atz≃ 5.3 and 5.6. Our sample includes data from the XQR-30 VLT large program, as well as new Keck/ESI observations of QSOs nearz∼ 5.5, for which we also acquire new [Cii] 158μm redshifts with ALMA. By measuring the Lyman continuum transmission profile in stacked QSO spectra, we find${\lambda }_{\mathrm{mfp}}={9.33}_{-1.80}^{+2.06}$,${5.40}_{-1.40}^{+1.47}$,${3.31}_{-1.34}^{+2.74}$, and${0.81}_{-0.48}^{+0.73}$pMpc atz= 5.08, 5.31, 5.65, and 5.93, respectively. Our results demonstrate thatλ_mfpincreases steadily and rapidly with time over 5 <z< 6. Notably, we find thatλ_mfpdeviates significantly from predictions based on a fully ionized and relaxed IGM as late asz= 5.3. By comparing our results to model predictions and indirectλ_mfpconstraints based on IGM Lyαopacity, we find that the evolution ofλ_mfpis consistent with scenarios wherein the IGM is still undergoing reionization and/or retains large fluctuations in the ionizing UV background well below redshift 6.