Surface deformation plays a key role in illuminating magma transport at active volcanoes, however, unambiguous separation of deep and shallow transport remains elusive. The Socorro Magma Body (SMB) lacks an upper crustal magma transport system, allowing us to link geodetic measurements with predictions of numerical models investigating rheologic heterogeneities and magma‐mush interaction in the mid‐/lower crust. New InSAR observations confirm that a pattern of central surface uplift surrounded by a region of subsidence (previously coined “sombrero” deformation) has persisted over >100 years at the SMB. Our models suggest this pattern may reflect the presence of a large (>100 km width), weaker‐than‐ambient, compliant region (CR) surrounding the mid‐crustal magma body. Interactions between a pressurizing (e.g., due to melt injection and/or volatile exsolution) sill‐like magma body and CR drive the sombrero pattern, depending on both viscoelastic relaxation and pressurization timescales, explaining its rare observation and transient nature.
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Abstract Free, publicly-accessible full text available October 28, 2024 -
Abstract Iron garnets that combine robust perpendicular magnetic anisotropy (PMA) with low Gilbert damping are desirable for studies of magnetization dynamics as well as spintronic device development. This paper reports the magnetic properties of low‐damping bismuth‐substituted iron garnet thin films (Bi0.8Y2.2Fe5O12) grown on a series of single‐crystal gallium garnet substrates. The anisotropy is dominated by magnetoelastic and growth‐induced contributions. Both stripe and triangular domains form during field cycling of PMA films, with triangular domains evident in films with higher PMA. Ferromagnetic resonance measurements show damping as low as 1.3 × 10−4with linewidths of 2.7 to 5.0 mT. The lower bound for the spin‐mixing conductance of BiYIG/Pt bilayers is similar to that of other iron garnet/Pt bilayers.
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Free, publicly-accessible full text available October 20, 2024
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Abstract Rossby wave breaking (RWB) can be manifested by the irreversible overturning of isentropes on constant potential vorticity (PV) surfaces. Traditionally, the type of breaking is categorized as anticyclonic (AWB) or cyclonic (CWB) and can be identified using the orientation of streamers of high potential temperature (
θ ) and lowθ air on a PV surface. However, an examination of the differences in RWB structure and their associated tropospheric impacts within these types remains unexplored. In this study, AWB and CWB are identified from overturning isentropes on the dynamic tropopause (DT), defined as the 2 potential vorticity unit (PVU; 1 PVU = 10−6K kg−1m2s−1) surface, in the ERA5 dataset during December, January, and February 1979–2019. Self-organizing maps (SOM), a machine learning method, is used to cluster the identified RWB events into archetypal patterns, or “flavors,” for each type. AWB and CWB flavors capture variations in theθ minima/maxima of each streamer and the localized meridionalθ gradient (∇θ ) flanking the streamers. Variations in the magnitude and position of ∇θ between flavors correspond to a diversity of jet structures leading to differences in vertical motion patterns and troposphere-deep circulations. A subset of flavors of AWB (CWB) events are associated with the development of strong surface high (low) pressure systems and the generation of extreme poleward moisture transport. For CWB, many events occurred in similar geographical regions, but the precipitation and moisture patterns were vastly different between flavors. Our findings suggest that the location, type, and severity of the tropospheric impacts from RWB are strongly dictated by RWB flavor.Significance Statement Large-scale atmospheric waves ∼15 km above Earth’s surface are responsible for the daily weather patterns that we experience. These waves can undergo wave breaking, a process that is analogous to ocean waves breaking along the seashore. Wave breaking events have been linked to extreme weather impacts at the surface including cold and heat waves, strong low pressure systems, and extreme precipitation events. Machine learning is used to identify and analyze different flavors, or patterns, of wave breaking events that result in differing surface weather impacts. Some flavors are able to generate notable channels of moisture that result in extreme high precipitation events. This is a crucial insight as forecasting of extreme weather events could be improved from this work.
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Abstract Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize antigens and enhance humoral immunity through multivalent antigen display. However, P-VLPs are thymus-dependent antigens that are themselves immunogenic and can induce B cell responses that may neutralize the platform. Here, we investigate thymus-independent DNA origami as an alternative material for multivalent antigen display using the receptor binding domain (RBD) of the SARS-CoV-2 spike protein, the primary target of neutralizing antibody responses. Sequential immunization of mice with DNA-based VLPs (DNA-VLPs) elicits protective neutralizing antibodies to SARS-CoV-2 in a manner that depends on the valency of the antigen displayed and on T cell help. Importantly, the immune sera do not contain boosted, class-switched antibodies against the DNA scaffold, in contrast to P-VLPs that elicit strong B cell memory against both the target antigen and the scaffold. Thus, DNA-VLPs enhance target antigen immunogenicity without generating scaffold-directed immunity and thereby offer an important alternative material for particulate vaccine design.
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Training the future synthetic biology workforce requires the opportunity for students to be exposed to biotechnology concepts and activities in secondary education. Detecting Wolbachia bacteria in arthropods using polymerase chain reaction (PCR) has become a common way for secondary students to investigate and apply recombinant DNA technology in the science classroom. Despite this important activity, cutting-edge biotechnologies such as clustered regularly interspaced short palindromic repeat (CRISPR)-based diagnostics have yet to be widely implemented in the classroom. To address this gap, we present a freeze-dried CRISPR-Cas12 sensing reaction to complement traditional recombinant DNA technology education and teach synthetic biology concepts. The reactions accurately detect Wolbachia from arthropod-derived PCR samples in under 2 h and can be stored at room temperature for over a month without appreciable degradation. The reactions are easy-to-use and cost less than $40 to implement for a classroom of 22 students including the cost of reusable equipment. We see these freeze-dried CRISPR-Cas12 reactions as an accessible way to incorporate synthetic biology education into the existing biology curriculum, which will expand biology educational opportunities in science, technology, engineering, and mathematics.more » « less