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Examination of pH dependency and orientation differences of membrane spanning alpha helices carrying a single or pair of buried histidine residues

https://doi.org/10.1016/j.bbamem.2020.183501

Afrose, Fahmida ; Martfeld, Ashley N. ; Greathouse, Denise V. ; Koeppe, Roger E. ( January 2021 , Biochimica et Biophysica Acta (BBA) - Biomembranes)
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Influence of interfacial tryptophan residues on an arginine-flanked transmembrane helix

https://doi.org/10.1016/j.bbamem.2019.183134

Sustich, Sara J. ; Afrose, Fahmida ; Greathouse, Denise V. ; Koeppe, Roger E. ( February 2020 , Biochimica et Biophysica Acta (BBA) - Biomembranes)

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Breaking the Backbone: Central Arginine Residues Induce Membrane Exit and Helix Distortions within a Dynamic Membrane Peptide

https://doi.org/10.1021/acs.jpcb.9b06034

McKay, Matthew J. ; Fu, Riqiang ; Greathouse, Denise V. ; Koeppe, Roger E. ( September 2019 , The Journal of Physical Chemistry B)

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Helix formation and stability in membranes

https://doi.org/10.1016/j.bbamem.2018.02.010

McKay, Matthew J. ; Afrose, Fahmida ; Koeppe, Roger E. ; Greathouse, Denise V. ( October 2018 , Biochimica et Biophysica Acta (BBA) - Biomembranes)

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Illuminating Disorder Induced by Glu in a Stable Arg-Anchored Transmembrane Helix

https://doi.org/10.1021/acsomega.1c02800

Price, Jake R. ; Afrose, Fahmida ; Greathouse, Denise V. ; Koeppe, II, Roger E. ( July 2021 , ACS Omega)
Transmembrane Helix Integrity versus Fraying To Expose Hydrogen Bonds at a Membrane–Water Interface

https://doi.org/10.1021/acs.biochem.8b01119

Afrose, Fahmida ; McKay, Matthew J. ; Mortazavi, Armin ; Suresh Kumar, Vasupradha ; Greathouse, Denise V. ; Koeppe, Roger E. ( December 2018 , Biochemistry)

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Flanking aromatic residue competition influences transmembrane peptide helix dynamics

https://doi.org/10.1002/1873-3468.13926

McKay, Matthew J. ; Greathouse, Denise V. ; Koeppe, II, Roger E. ( September 2020 , FEBS Letters)

To address biophysical principles and lipid interactions that underlie the properties of membrane proteins, modifications that vary the neighbors of tryptophan residues in the highly dynamic transmembrane helix of GW^4,20ALP23 (acetyl‐GGAW⁴A(LA)₆LAW²⁰AGA‐amide) were examined using deuterium NMR spectroscopy. It was found that L^5,19GW^4,20ALP23, a sequence isomer of the low to moderately dynamic GW^5,19ALP23, remains highly dynamic. By contrast, a removal of W4 to produce F^4,5GW²⁰ALP23 restores a low level of dynamic averaging, similar to that of the F^4,5GW¹⁹ALP23 helix. Interestingly, a high level of dynamic averaging requires the presence of both tryptophan residues W4 and W20, on opposite faces of the helix, and does not depend on whether residue 5 is Leu or Ala. Aspects of helix unwinding and potential oligomerization are discussed with respect to helix dynamic averaging and the locations of particular residues at a phosphocholine membrane interface.

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Control of Transmembrane Helix Dynamics by Interfacial Tryptophan Residues

https://doi.org/10.1016/j.bpj.2018.04.016

McKay, Matthew J. ; Martfeld, Ashley N. ; De Angelis, Anna A. ; Opella, Stanley J. ; Greathouse, Denise V. ; Koeppe, Roger E. ( June 2018 , Biophysical Journal)

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Lipid-Dependent Titration of Glutamic Acid at a Bilayer Membrane Interface

https://doi.org/10.1021/acsomega.1c00276

McKay, Matthew J. ; Marr, Kelsey A. ; Price, Jake R. ; Greathouse, Denise V. ; Koeppe, II, Roger E. ( March 2021 , ACS Omega)
Membrane Bending Moduli of Coexisting Liquid Phases Containing Transmembrane Peptide

https://doi.org/10.1016/j.bpj.2018.03.026

Usery, Rebecca D. ; Enoki, Thais A. ; Wickramasinghe, Sanjula P. ; Nguyen, Vanessa P. ; Ackerman, David G. ; Greathouse, Denise V. ; Koeppe, Roger E. ; Barrera, Francisco N. ; Feigenson, Gerald W. ( May 2018 , Biophysical Journal)

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