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Under healthy conditions, the pancreas responds to a glucose challenge by releasing insulin. Insulin suppresses lipolysis in adipose tissue, thereby decreasing plasma glycerol concentration, and it regulates plasma glucose concentration through action in muscle and liver. Insulin resistance (IR) occurs when more insulin is required to achieve the same effects, and IR may be tissue-specific. IR emerges during puberty as a result of high concentrations of growth hormone and is worsened by youth-onset obesity. Adipose, liver, and muscle tissue exhibit distinct dose-dependent responses to insulin in multi-phase hyperinsulinemic-euglycemic (HE) clamps, but the HE clamp protocol does not address potential differences in the dynamics of tissue-specific insulin responses. Changes to the dynamics of insulin responses would alter glycemic control in response to a glucose challenge. To investigate the dynamics of insulin acting on adipose tissue, we developed a novel differential-equations based model that describes the coupled dynamics of glycerol concentrations and insulin action during an oral glucose tolerance test in female adolescents with obesity and IR. We compared these dynamics to the dynamics of insulin acting on muscle and liver as assessed with the oral minimal model applied to glucose and insulin data collected under the same protocol. We found that the action of insulin on glycerol peaks approximately 67 min earlier ( p < 0.001) and follows the dynamics of plasma insulin more closely compared to insulin action on glucose as assessed by the parameters representing the time constants for insulin action on glucose and glycerol ( p < 0.001). These findings suggest that the dynamics of insulin action show tissue-specific differences in our IR adolescent population, with adipose tissue responding to insulin more quickly compared to muscle and liver. Improved understanding of the tissue-specific dynamics of insulin action may provide novel insights into the progression of metabolic disease in patient populations with diverse metabolic phenotypes. 

Eventdisplay is a reconstruction and analysis pipeline for data of Imaging Atmospheric Cherenkov Telescopes (IACT). It has been primarily developed for VERITAS and CTA analysis. Code, analysis files and scripts can be find in the Eventdisplay GitHub Organisation. Docker images are available from the Eventdisplay container registry. In case Eventdisplay is used in a research project, please cite the following publication: Maier, G.; Holder, J., Eventdisplay: An Analysis and Reconstruction Package for Ground-based Gamma-ray Astronomy, 35th International Cosmic Ray Conference. 10-20 July, 2017. Bexco, Busan, Korea, Proceedings of Science, Vol. 301. Online at [https://pos.sissa.it/cgi-bin/reader/conf.cgi?confid=301], id.747 arXiv:1708.04048 This release adds zstd to the alma linux containers. What's Changed v5.13.1 - add zstd to almalinux containers. by @GernotMaier in https://github.com/Eventdisplay/Eventdisplay/pull/164 Full Changelog: https://github.com/Eventdisplay/Eventdisplay/compare/v5.13.0...v5.13.2 

Abstract The recent IceCube detection of TeV neutrino emission from the nearby active galaxy NGC 1068 suggests that active galactic nuclei (AGNs) could make a sizable contribution to the diffuse flux of astrophysical neutrinos. The absence of TeVγ-rays from NGC 1068 indicates neutrino production in the vicinity of the supermassive black hole, where the high radiation density leads toγ-ray attenuation. Therefore, any potential neutrino emission from similar sources is not expected to correlate with high-energyγ-rays. Disk-corona models predict neutrino emission from Seyfert galaxies to correlate with keV X-rays because they are tracers of coronal activity. Using through-going track events from the Northern Sky recorded by IceCube between 2011 and 2021, we report results from a search for individual and aggregated neutrino signals from 27 additional Seyfert galaxies that are contained in the Swift's Burst Alert Telescope AGN Spectroscopic Survey. Besides the generic single power law, we evaluate the spectra predicted by the disk-corona model assuming stochastic acceleration parameters that match the measured flux from NGC 1068. Assuming all sources to be intrinsically similar to NGC 1068, our findings constrain the collective neutrino emission from X-ray bright Seyfert galaxies in the northern sky, but, at the same time, show excesses of neutrinos that could be associated with the objects NGC 4151 and CGCG 420-015. These excesses result in a 2.7σsignificance with respect to background expectations. 

Abstract The Breakthrough Listen Initiative is conducting a program using multiple telescopes around the world to search for “technosignatures”: artificial transmitters of extraterrestrial origin from beyond our solar system. The Very Energetic Radiation Imaging Telescope Array System (VERITAS) Collaboration joined this program in 2018 and provides the capability to search for one particular technosignature: optical pulses of a few nanoseconds in duration detectable over interstellar distances. We report here on the analysis and results of dedicated VERITAS observations of Breakthrough Listen targets conducted in 2019 and 2020 and of archival VERITAS data collected since 2012. Thirty hours of dedicated observations of 136 targets and 249 archival observations of 140 targets were analyzed and did not reveal any signals consistent with a technosignature. The results are used to place limits on the fraction of stars hosting transmitting civilizations. We also discuss the minimum pulse sensitivity of our observations and present VERITAS observations of CALIOP: a space-based pulsed laser on board the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations. The detection of these pulses with VERITAS, using the analysis techniques developed for our technosignature search, allows a test of our analysis efficiency and serves as an important proof of principle. 

We report a study of the inelasticity distribution in the scattering of neutrinos of energy 80–560 GeV off nucleons. Using atmospheric muon neutrinos detected in IceCube’s sub-array DeepCore during 2012–2021, we fit the observed inelasticity in the data to a parameterized expectation and extract the values that describe it best. Finally, we compare the results to predictions from various combinations of perturbative QCD calculations and atmospheric neutrino flux models. Published by the American Physical Society2025 

Abstract The nature of dark matter remains unresolved in fundamental physics. Weakly Interacting Massive Particles (WIMPs), which could explain the nature of dark matter, can be captured by celestial bodies like the Sun or Earth, leading to enhanced self-annihilation into Standard Model particles including neutrinos detectable by neutrino telescopes such as the IceCube Neutrino Observatory. This article presents a search for muon neutrinos from the center of the Earth performed with 10 years of IceCube data using a track-like event selection. We considered a number of WIMP annihilation channels ($$\chi \chi \rightarrow \tau ^+\tau ^-$$ $\chi \chi \to {\tau }^{+}{\tau }^{-}$/$$W^+W^-$$ $W^{+}{W}^{-}$/$$b\bar{b}$$ $b\overline{b}$) and masses ranging from 10 GeV to 10 TeV. No significant excess over background due to a dark matter signal was found while the most significant result corresponds to the annihilation channel$$\chi \chi \rightarrow b\bar{b}$$ $\chi \chi \to b\overline{b}$for the mass$$m_{\chi }=250$$ $m_{\chi }=250$ GeV with a post-trial significance of$$1.06\sigma $$ $1.06\sigma$. Our results are competitive with previous such searches and direct detection experiments. Our upper limits on the spin-independent WIMP scattering are world-leading among neutrino telescopes for WIMP masses$$m_{\chi }>100$$ $m_{\chi }>100$ GeV.