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This work proposes a unified framework for efficient estimation under latent space modeling of heterogeneous networks. We consider a class of latent space models that decompose latent vectors into shared and network-specific components across networks. We develop a novel procedure that first identifies the shared latent vectors and further refines estimates through efficient score equations to achieve statistical efficiency. Oracle error rates for estimating the shared and heterogeneous latent vectors are established simultaneously. The analysis framework offers remarkable flexibility, accommodating various types of edge weights under general distributions. 

In biomedical studies, testing for differences in covariance may offer scientific insights, especially when differences are driven by complex joint behavior between features. However, when differences in joint behavior are weakly dispersed across many dimensions and arise from differences in low-rank structures within the data, as is often the case in genomics and neuroimaging, existing two-sample covariance testing methods may suffer from power loss. The Ky-Fan(k) norm, defined by the sum of the top k singular values, is a simple and intuitive matrix norm able to capture signals caused by differences in low-rank structures between matrices, but its statistical properties in hypothesis testing have not been studied well. In this paper, we investigate the behavior of the Ky-Fan(k) norm in two-sample covariance testing. Ultimately, we propose a novel methodology, rank-adaptive covariance testing (RACT), which is able to leverage differences in low-rank structures found in the covariance matrices of two groups in order to maximize power. RACT uses permutation for statistical inference, ensuring an exact Type I error control. We validate RACT in simulation studies and evaluate its performance when testing for differences in gene expression networks between two types of lung cancer, as well as testing for covariance heterogeneity in diffusion tensor imaging data taken on two different scanner types. 

Unidimensional item response theory (IRT) models are widely used even in settings where assessment data exhibit subtle forms of multidimensionality. Recent empirical evidence suggests that when item difficulty is associated with dimensionality, asymmetric item characteristic curves (ICCs) emerge in the unidimensional approximation. Through theoretical derivation and extensive simulation, this paper develops a framework for understanding the emergence and the degree of ICC asymmetry in UIRT models when applied to multidimensional data with difficulty–dimensionality associations. An empirical analysis of the Virginia Language & Literacy Screener (VALLSS) confirms the predicted patterns. These results highlight ICC asymmetry as an anticipated consequence of unidimensional approximation and underscore its relevance for applications such as vertical scaling and test linking. 

Abstract Mediation analysis aims to assess if, and how, a certain exposure influences an outcome of interest through intermediate variables. This problem has recently gained a surge of attention due to the tremendous need for such analyses in scientific fields. Testing for the mediation effect (ME) is greatly challenged by the fact that the underlying null hypothesis (i.e. the absence of MEs) is composite. Most existing mediation tests are overly conservative and thus underpowered. To overcome this significant methodological hurdle, we develop an adaptive bootstrap testing framework that can accommodate different types of composite null hypotheses in the mediation pathway analysis. Applied to the product of coefficients test and the joint significance test, our adaptive testing procedures provide type I error control under the composite null, resulting in much improved statistical power compared to existing tests. Both theoretical properties and numerical examples of the proposed methodology are discussed. 

Abstract Wilk’s theorem, which offers universal chi-squared approximations for likelihood ratio tests, is widely used in many scientific hypothesis testing problems. For modern datasets with increasing dimension, researchers have found that the conventional Wilk’s phenomenon of the likelihood ratio test statistic often fails. Although new approximations have been proposed in high dimensional settings, there still lacks a clear statistical guideline regarding how to choose between the conventional and newly proposed approximations, especially for moderate-dimensional data. To address this issue, we develop the necessary and sufficient phase transition conditions for Wilk’s phenomenon under popular tests on multivariate mean and covariance structures. Moreover, we provide an in-depth analysis of the accuracy of chi-squared approximations by deriving their asymptotic biases. These results may provide helpful insights into the use of chi-squared approximations in scientific practices.