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Substituent Effects and Mechanistic Insights on the Catalytic Activities of (Tetraarylcyclopentadienone)iron Carbonyl Compounds in Transfer Hydrogenations and Dehydrogenations

https://doi.org/10.1021/acs.organomet.3c00284

Werley, Bryn K.; Hou, Xintong; Bertonazzi, Evan P.; Chianese, Anthony; Funk, Timothy W. (October 2023, Organometallics)
Reducing Challenges in Organic Synthesis with Stereoselective Hydrogenation and Tandem Catalysis

https://doi.org/doi.org/10.1021/jacs.1c00750

Parker, Patrick D.; Hou, Xintong; and Dong, Vy M. (January 2021, ACS)
null (Ed.)
Tandem catalysis enables the rapid construction of complex architectures from simple building blocks. This Perspective shares our interest in combining stereoselective hydrogenation with transformations such as isomerization, oxidation, and epimerization to solve diverse challenges. We highlight the use of tandem hydrogenation for preparing complex natural products from simple prochiral building blocks and present tandem catalysis involving transfer hydrogenation and dynamic kinetic resolution. Finally, we underline recent breakthroughs and opportunities for asymmetric hydrogenation.
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Copper‐Phosphido Catalysis: Enantioselective Addition of Phosphines to Cyclopropenes**

https://doi.org/10.1002/ange.202306511

Daniels, Brian S.; Hou, Xintong; Corio, Stephanie A.; Weissman, Lindsey M.; Dong, Vy M.; Hirschi, Jennifer S.; Nie, Shaozhen (July 2023, Angewandte Chemie)

Abstract We describe a copper catalyst that promotes the addition of phosphines to cyclopropenes at ambient temperature. A range of cyclopropylphosphines bearing different steric and electronic properties can now be accessed in high yields and enantioselectivities. Enrichment of phosphorus stereocenters is also demonstrated via a Dynamic Kinetic Asymmetric Transformation (DyKAT) process. A combined experimental and theoretical mechanistic study supports an elementary step featuring insertion of a Cu^I‐phosphido into a carbon‐carbon double bond. Density functional theory calculations reveal migratory insertion as the rate‐ and stereo‐determining step, followed by asyn‐protodemetalation.
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