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  1. Videoconferencing usage has surged in recent years, but current platforms present significant accessibility barriers for the 430 million d/Deaf or hard of hearing people worldwide. Informed by prior work examining accessibility barriers in current videoconferencing platforms, we designed and developed Jod, a videoconferencing platform to facilitate communication in mixed hearing groups. Key features include support for customizing visual layouts and a notification system to request attention and influence behavior. Using Jod, we conducted six mixed hearing group sessions with 34 participants, including 18 d/Deaf or hard of hearing participants, 10 hearing participants, and 6 sign language interpreters. We found participants engaged in visual layout rearrangements based on their hearing ability and dynamically adapted to the changing group communication context, and that notifications were useful but raised a need for designs to cause fewer interruptions. We provide insights for future videoconferencing designs and conclude with recommendations for conducting mixed hearing studies. 
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  2. Abstract

    Studies using 16S rRNA and shotgun metagenomics typically yield different results, usually attributed to PCR amplification biases. We introduce Greengenes2, a reference tree that unifies genomic and 16S rRNA databases in a consistent, integrated resource. By inserting sequences into a whole-genome phylogeny, we show that 16S rRNA and shotgun metagenomic data generated from the same samples agree in principal coordinates space, taxonomy and phenotype effect size when analyzed with the same tree.

     
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  3. Abstract

    Riboflavin is an essential cofactor in many enzymatic processes and in the production of flavin adenine dinucleotide (FAD). Here, we report that the partial depletion of riboflavin through knockdown of theC. elegansriboflavin transporter 1 (rft‐1) promotes metabolic health by reducing intracellular flavin concentrations. Knockdown ofrft‐1significantly increases lifespan in a manner dependent upon AMP‐activated protein kinase (AMPK)/aak‐2, the mitochondrial unfolded protein response, and FOXO/daf‐16. Riboflavin depletion promotes altered energetic and redox states and increases adiposity, independent of lifespan genetic dependencies. Riboflavin‐depleted animals also exhibit the activation of caloric restriction reporters without any reduction in caloric intake. Our findings indicate that riboflavin depletion activates an integrated hormetic response that promotes lifespan and healthspan inC. elegans.

     
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