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Abstract Kirigami is defined as the ancient Japanese art of cutting and folding paper to create three-dimensional structures, which is a subset of the larger term. Recent developments in kirigami-based structures have sparked interest in the engineering community for the development of mechanical metastructures with customized behavior such as negative Poisson’s ratio, out-of-plane buckling, and soft robot locomotion. In this manuscript, nonlinear springs based on kirigami are developed; the springs can be used to create customized nonlinear oscillators and vibration suppression systems. A Helmholtz-Duffing oscillator with nonlinear damping is created by attaching a mass to a smooth track with the kirigami springs attached to it. Kirigami springs were made by strategically cutting plastic sheets in predetermined patterns and arranging them in a ring. Identification of the unknown system parameters is accomplished through the use of a two-step procedure. To determine the quasi-static behavior of the spring, it was first subjected to tensile testing. These parameters serve as the foundation for developing a strategy for determining the unknown energy loss parameters in a system. In the second step, the Method of Multiple Scales is used to develop an approximate solution for the transient response, which is then tested. This solution is coupled with an optimization routine that, by modifying the unknown model parameters, seeks to reduce the error between the experimental free oscillations and the developed analytical solution as closely as possible. 

Abstract Modulation of autophagy, specifically its inhibition, stands to transform the capacity to effectively treat a broad range of cancers. However, the clinical efficacy of autophagy inhibitors has been inconsistent. To delineate clinical and epidemiological features associated with autophagy inhibition and a positive oncological clinical response, a retrospective analysis of patients is conducted treated with hydroxychloroquine, a known autophagy inhibitor. A direct correlation between smoking status and inhibition of autophagy with hydroxychloroquine is identified. Recognizing that smoking is associated with elevated circulating levels of carbon monoxide (CO), it is hypothesized that supplemental CO can amplify autophagy inhibition. A novel, gas‐entrapping material containing CO in a pre‐clinical model is applied and demonstrated that CO can dramatically increase the cytotoxicity of autophagy inhibitors and significantly inhibit the growth of tumors when used in combination. These data support the notion that safe, therapeutic levels of CO can markedly enhance the efficacy of autophagy inhibitors, opening a promising new frontier in the quest to improve cancer therapies.