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Creators/Authors contains: "Jiang, Fan"

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  1. We analyzed data from a survey administered to 1,212 respondents living in superstorm Hurricane Sandy-affected areas. We estimated the effect of having experienced hurricane-induced disruptions to utility services, such as electricity, water, gas, phone service, and public transportation, on having an evacuation plan. Around 39% of respondents reported having an evacuation plan in case a hurricane affects their neighborhood this year. Respondents who had experienced disruptions to electricity supply had an approximately 11 percentage-point higher likelihood of having an evacuation plan than those who had experienced no such disruptions. Respondents who had experienced monetary losses from Hurricane Sandy had around a five percentage-point higher likelihood of having an evacuation plan compared with those who had not. Among control variables, prior evacuation, distance to the coastline, residence in a flood zone, concern about the impacts of future natural disaster events, had window protection, and household members being disabled, each had an association with residents’ future evacuation planning and hurricane preparedness. In light of these findings, we discuss the policy implications of our findings for improving disaster management in hurricane-prone areas. 
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  2. Abstract BackgroundUncovering the functional relevance underlying verbal declarative memory (VDM) genome-wide association study (GWAS) results may facilitate the development of interventions to reduce age-related memory decline and dementia. MethodsWe performed multi-omics and pathway enrichment analyses of paragraph (PAR-dr) and word list (WL-dr) delayed recall GWAS from 29,076 older non-demented individuals of European descent. We assessed the relationship between single-variant associations and expression quantitative trait loci (eQTLs) in 44 tissues and methylation quantitative trait loci (meQTLs) in the hippocampus. We determined the relationship between gene associations and transcript levels in 53 tissues, annotation as immune genes, and regulation by transcription factors (TFs) and microRNAs. To identify significant pathways, gene set enrichment was tested in each cohort and meta-analyzed across cohorts. Analyses of differential expression in brain tissues were conducted for pathway component genes. ResultsThe single-variant associations of VDM showed significant linkage disequilibrium (LD) with eQTLs across all tissues and meQTLs within the hippocampus. Stronger WL-dr gene associations correlated with reduced expression in four brain tissues, including the hippocampus. More robust PAR-dr and/or WL-dr gene associations were intricately linked with immunity and were influenced by 31 TFs and 2 microRNAs. Six pathways, including type I diabetes, exhibited significant associations with both PAR-dr and WL-dr. These pathways included fifteen MHC genes intricately linked to VDM performance, showing diverse expression patterns based on cognitive status in brain tissues. ConclusionsVDM genetic associations influence expression regulation via eQTLs and meQTLs. The involvement of TFs, microRNAs, MHC genes, and immune-related pathways contributes to VDM performance in older individuals. 
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  3. Hurricane evacuation has become an increasingly complicated activity in the U.S. as it involves moving many people who live along the Atlantic coast and Gulf coast within a very limited time. A good deal of research has been conducted on hurricane evacuation, but only a limited number of studies have looked into the timing aspect of evacuation. This paper intends to contribute to the literature on evacuation timing decisions by investigating what factors influence the time preference at the household level. Two hurricane survey data sets were used to analyze household evacuation behaviors across the Gulf coast as well as the Northeast and Mid-Atlantic coast in a comparative perspective. Using the Heckman selection model, we examined various factors identified in the literature on the two possible outcomes (evacuation and early evacuation). We found that the most important determinants of evacuation were prior evacuation experience, evacuation orders, and risk perceptions, while the most important determinants of early evacuation were prior evacuation experiences, days spent at the evacuation destination, and the cost of evacuation. Socioeconomic factors also influenced the two decisions but differently. These results provide implications for future hurricane evacuation planning and for improving emergency management practices. 
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