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Public artwork, from vibrant wall murals to captivating sculptures, can enhance the aesthetic of urban spaces, foster a sense of community and cultural identity, and help attract visitors. Despite its benefits, most public art is visual, making it often inaccessible to blind and low vision (BLV) people. In this workshop paper, we first draw on art literature to help define the space of public art, identify key differences with curated art shown in museums or galleries, and discuss implications for accessibility. We then enumerate how existing art accessibility techniques may (or may not) transfer to urban art spaces. We close by presenting future research directions and reflecting on the growing role of AI in making art accessible. 

Summary 3′,3′‐cyclic GMP‐AMP (cGAMP) is the third cyclic dinucleotide (CDN) to be discovered in bacteria. No activators of cGAMP signaling have yet been identified, and the signaling pathways for cGAMP have been inferred to display a narrow distribution based upon the characterized synthases, DncV and Hypr GGDEFs. Here, we report that the ubiquitous second messenger cyclic AMP (cAMP) is an activator of the Hypr GGDEF enzyme GacB fromMyxococcus xanthus. Furthermore, we show that GacB is inhibited directly by cyclic di‐GMP, which provides evidence for cross‐regulation between different CDN pathways. Finally, we reveal that the HD‐GYP enzyme PmxA is a cGAMP‐specific phosphodiesterase (GAP) that promotes resistance to osmotic stress inM. xanthus. A signature amino acid change in PmxA was found to reprogram substrate specificity and was applied to predict the presence of non‐canonical HD‐GYP phosphodiesterases in many bacterial species, including phyla previously not known to utilize cGAMP signaling.