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Abstract Astronomical objects that change rapidly give us insight into extreme environments, allowing us to identify new phenomena, test fundamental physics, and probe the Universe on all scales. Transient and variable radio sources range from the cosmological, such as gamma-ray bursts, to much more local events, such as massive flares from stars in our Galactic neighbourhood. The capability to observe the sky repeatedly, over many frequencies and timescales, has allowed us to explore and understand dynamic phenomena in a way that has not been previously possible. In the past decade, there have been great strides forward as we prepared for the revolution in time domain radio astronomy that is being enabled by the SKA Observatory telescopes, the SKAO pathfinders and precursors, and other ‘next generation’ radio telescopes. Hence, it is timely to review the current status of the field and summarise the developments that have happened to get to our current point. This review focuses on image domain (or ‘slow’) transients, on timescales of seconds to years. We discuss the physical mechanisms that cause radio variability and the classes of radio transients that result. We then outline what an ideal image domain radio transients survey would look like and summarise the history of the field, from targeted observations to surveys with existing radio telescopes. We discuss methods and approaches for transient discovery and classification and identify some of the challenges in scaling up current methods for future telescopes. Finally, we present our current understanding of the dynamic radio sky, in terms of source populations and transient rates, and look at what we can expect from surveys on future radio telescopes. 

Abstract Galactic radio transients (GRTs) are mysterious short-lived (∼days to months) radio transients that are quiet at all other wavelengths. Until now, roughly half a dozen such sources have been reported, predominantly towards the Galactic center. However, no unifying properties have been identified among these, leaving their nature, emission mechanism, and even classification poorly understood. Due to the lack of periodic and uniform radio observations over wide areas of the Galactic plane until now, the sample size of such transients remained limited. Here, we use radio observations from the Australian SKA Pathfinder’s Variables and Slow Transients survey to discover six new radio transients along the Galactic plane that resemble GRTs. Detailed investigation of archival data suggests that these sources may be divided into two classes: sources that exhibit sporadic, pulse-like (minutes) radio emission, and sources that exhibit long-term (weeks) flaring-type radio emission. For the short-time variable sources, we draw similarities between optically bright long-period radio transients and our sample to propose wide-orbit (∼days) white dwarf binaries as underlying sources. For sources that show long-term outbursts, we draw comparisons between dust-obscured outbursts from WD binaries and our sample. These results could imply that the ongoing wide-field radio surveys are uncovering radio emission from subpopulations of WD binaries that were previously unexplored. 

Abstract We report the discovery and timing of two pulsars from a sample of four circularly polarized sources identified in radio continuum images taken as part of the Australian SKA Pathfinder Variables and Slow Transients survey. Observations with the Parkes (Murriyang) radio telescope confirmed both sources as normal pulsars with high dispersion measures (DMs). PSR J1646−4451 has a spin period of 217 ms and a DM of 928 cm⁻³pc, while PSR J1837−0616 exhibits a spin period of 118 ms and a DM of 793 cm⁻³pc. These pulsars show extreme pulse broadening due to scattering, with measured scattering timescales of 117 ms and 75 ms at observing frequencies of ∼1.8 GHz, respectively. These measurements imply extrapolated scattering timescales at 1 GHz of ∼1346 ms and 740 ms, placing them among the most heavily scattered known pulsars. Our findings underscore the potential of using circular polarization in radio continuum images as a tool for identifying highly scattered pulsars. Future wide-field radio continuum surveys are poised to uncover a broader population of extreme pulsars, particularly those that are heavily scattered at 1.4 GHz, intrinsically faint, or residing in binaries—offering valuable insights into both pulsar demographics and the complex structure of the ionized interstellar medium. 

ABSTRACT We present the discovery of radio emission from the Be/X-ray binary A0538−66 with the Australian Square Kilometre Array Pathfinder, and results from a subsequent weekly monitoring campaign with the MeerKAT radio telescope. A0538−66, located in the Large Magellanic Cloud, hosts a neutron star with a short spin period ($$P \approx 69$$ ms) in a highly eccentric $${\approx} \ 16.6$$-d orbit . Its rare episodes of super-Eddington accretion, rapid optical and X-ray flares, and other peculiar properties make it an interesting system among high-mass X-ray binaries. Our MeerKAT data reveal that it is also one of the most radio-luminous neutron star X-ray binaries observed to date, reaching $${\approx} \ 3 \times 10^{22} \, \text{erg} \, \text{s}^{-1} \, \text{Hz}^{-1}$$ (at 1.28 GHz), with radio emission that appears to be orbitally modulated. We consider several possible mechanisms for the radio emission, and place A0538−66 in context by comparing it to similar systems. 

Abstract The Variables and Slow Transients (VAST) Survey on the Australian SKA Pathfinder (ASKAP) is designed to systematically explore the dynamic radio sky, detecting sources that vary on timescales from minutes to several years. In this paper, we present Data Release 1 of the VAST Extragalactic Survey, which targets slowly evolving synchrotron transients in the southern sky. The observations were carried out between June 2023 and May 2025, comprising 2 945 images of 276 fields spanning$$\sim 12\,300\ \mathrm{deg}^2$$, observed at 888 MHz with a typical rms sensitivity of 0.24 mJy$$\mathrm{beam}^{-1}$$and 12–20 arcsec resolution. Each field was revisited approximately every two months, yielding 10 or 11 observations per field. The VAST pipeline extracts the light curves for all the observed sources, and additional filters are implemented to improve the reliability of the resulting light curve database. The light curve database contains 0.5 million sources and 6.4 million individual measurements, publicly available through the CSIRO data access portal. An untargeted variability search yields 117 astrophysical variables, including 27 pulsars, 40 radio stars (10 newly detected at radio wavelengths), 44 active galactic nuclei, two optically identified supernovae, one supernova candidate, one brown dwarf, and two sources without multi-wavelength counterparts that are yet to be identified. This data release provides the first large-scale, high-cadence, uniform view of long-term radio variability in the extragalactic sky and lays the groundwork for future population studies of radio transients with ASKAP. 

Abstract Human intestinal organoids (HIOs) are vital for modeling intestinal development, disease, and therapeutic tissue regeneration. However, their susceptibility to stress, immunological attack, and environmental fluctuations limits their utility in research and therapeutic applications. This study evaluated the effectiveness of temporary silk protein‐based layer‐by‐layer (LbL) nanoencapsulation technique to enhance the viability and functions of HIOs against common biomedical stressors, without compromising their native functions. Cell viability and differentiation capacity are assessed, finding that nanoencapsulation significantly improved HIO survival under the various environmental perturbations studied without compromising cellular functionality. Post‐stress exposures, the encapsulated HIOs still successfully differentiated into essential intestinal cell types such as enterocytes, goblet cells, enteroendocrine cells, and Paneth cells. Moreover, the silk nanocoatings effectively protected against environmental stressors such as ultraviolet (UV) light exposure, protease degradation, antibody binding, and cytokine‐induced inflammation. This nanoencapsulation technique shows promise for advancing HIO applications in disease modeling, drug testing, and potential transplantation therapies. 

Encapsulation of single cells is a powerful technique used in various fields, such as regenerative medicine, drug delivery, tissue regeneration, cell-based therapies, and biotechnology. It offers a method to protect cells by providing cytocompatible coatings to strengthen cells against mechanical and environmental perturbations. Silk fibroin, derived from the silkworm Bombyx mori, is a promising protein biomaterial for cell encapsulation due to the cytocompatibility and capacity to maintain cell functionality. Here, THP-1 cells, a human leukemia monocytic cell line, were encapsulated with chemically modified silk polyelectrolytes through electrostatic layer-by-layer deposition. The effectiveness of the silk nanocoating was assessed using scanning electron microscopy (SEM) and confocal microscopy and on cell viability and proliferation by Alamar Blue assay and live/dead staining. An analysis of the mechanical properties of the encapsulated cells was conducted using atomic force microscopy (AFM) nanoindentation to measure elasticity maps and cellular stiffness. After the cells were encapsulated in silk, an increase in their stiffness was observed. Based on this observation, we developed a mechanical predictive model to estimate the variations in stiffness in relation to the thickness of the coating. By tuning the cellular assembly and biomechanics, these encapsulations promote systems that protect cells during biomaterial deposition or processing in general.