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  1. ; ; ; ( , npj Vaccines)
    Abstract

    Despite considerable effort, malaria remains a major public health burden. Malaria is caused by fivePlasmodiumspecies and is transmitted to humans via the femaleAnophelesmosquito. The development of malaria vaccines against the liver and blood stages has been challenging. Therefore, malaria elimination strategies advocate integrated measures, including transmission-blocking approaches. Designing an effective transmission-blocking strategy relies on a sophisticated understanding of the molecular mechanisms governing the interactions between the mosquito midgut molecules and the malaria parasite. Here we review recent advances in the biology of malaria transmission, focusing on molecular interactions betweenPlasmodiumandAnophelesmosquito midgut proteins. We provide an overview of parasite and mosquito proteins that are either targets for drugs currently in clinical trials or candidates of promising transmission-blocking vaccines.

     
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