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The long noncoding RNA COLDAIR is necessary for the repression of a floral repressor FLOWERING LOCUS C (FLC) during vernalization in Arabidopsis thaliana. The repression of FLC is mediated by increased enrichment of Polycomb Repressive Complex 2 (PRC2) and subsequent trimethylation of Histone H3 Lysine 27 (H3K27me3) at FLC chromatin. In this study we found that the association of COLDAIR with chromatin occurs only at the FLC locus and that the central region of the COLDAIR transcript is critical for this interaction. A modular motif in COLDAIR is responsible for the association with PRC2 in vitro, and the mutations within the motif that reduced the association of COLDAIR with PRC2 resulted in vernalization insensitivity. The vernalization insensitivity caused by mutant COLDAIR was rescued by the ectopic expression of the wild-type COLDAIR. Our study reveals the molecular framework in which COLDAIR lncRNA mediates the PRC2-mediated repression of FLC during vernalization. 

Context. Until recently, the 3D shape, and therefore density (when combining the volume estimate with available mass estimates), and surface topography of the vast majority of the largest ( D   ≥ 100 km) main-belt asteroids have remained poorly constrained. The improved capabilities of the SPHERE/ZIMPOL instrument have opened new doors into ground-based asteroid exploration. Aims. To constrain the formation and evolution of a representative sample of large asteroids, we conducted a high-angular-resolution imaging survey of 42 large main-belt asteroids with VLT/SPHERE/ZIMPOL. Our asteroid sample comprises 39 bodies with D   ≥ 100 km and in particular most D   ≥ 200 km main-belt asteroids (20/23). Furthermore, it nicely reflects the compositional diversity present in the main belt as the sampled bodies belong to the following taxonomic classes: A, B, C, Ch/Cgh, E/M/X, K, P/T, S, and V. Methods. The SPHERE/ZIMPOL images were first used to reconstruct the 3D shape of all targets with both the ADAM and MPCD reconstruction methods. We subsequently performed a detailed shape analysis and constrained the density of each target using available mass estimates including our own mass estimates in the case of multiple systems. Results. The analysis of the reconstructed shapes allowed us to identify two families of objects as a function of their diameters, namely “spherical” and “elongated” bodies. A difference in rotation period appears to be the main origin of this bimodality. In addition, all but one object (216 Kleopatra) are located along the Maclaurin sequence with large volatile-rich bodies being the closest to the latter. Our results further reveal that the primaries of most multiple systems possess a rotation period of shorter than 6 h and an elongated shape ( c ∕ a ≤ 0.65). Densities in our sample range from ~1.3 g cm −3 (87 Sylvia) to ~4.3 g cm −3 (22 Kalliope). Furthermore, the density distribution appears to be strongly bimodal with volatile-poor ( ρ ≥ 2.7 g cm −3 ) and volatile-rich ( ρ ≤ 2.2 g cm −3 ) bodies. Finally, our survey along with previous observations provides evidence in support of the possibility that some C-complex bodies could be intrinsically related to IDP-like P- and D-type asteroids, representing different layers of a same body (C: core; P/D: outer shell). We therefore propose that P/ D-types and some C-types may have the same origin in the primordial trans-Neptunian disk. 

A<sc>bstract</sc> A measurement is performed of Higgs bosons produced with high transverse momentum (p_T) via vector boson or gluon fusion in proton-proton collisions. The result is based on a data set with a center-of-mass energy of 13 TeV collected in 2016–2018 with the CMS detector at the LHC and corresponds to an integrated luminosity of 138 fb⁻¹. The decay of a high-p_THiggs boson to a boosted bottom quark-antiquark pair is selected using large-radius jets and employing jet substructure and heavy-flavor taggers based on machine learning techniques. Independent regions targeting the vector boson and gluon fusion mechanisms are defined based on the topology of two quark-initiated jets with large pseudorapidity separation. The signal strengths for both processes are extracted simultaneously by performing a maximum likelihood fit to data in the large-radius jet mass distribution. The observed signal strengths relative to the standard model expectation are$$ {4.9}_{-1.6}^{+1.9} $$ ${4.9}_{-1.6}^{+1.9}$and$$ {1.6}_{-1.5}^{+1.7} $$ ${1.6}_{-1.5}^{+1.7}$for the vector boson and gluon fusion mechanisms, respectively. A differential cross section measurement is also reported in the simplified template cross section framework. 

Abstract Computing demands for large scientific experiments, such as the CMS experiment at the CERN LHC, will increase dramatically in the next decades. To complement the future performance increases of software running on central processing units (CPUs), explorations of coprocessor usage in data processing hold great potential and interest. Coprocessors are a class of computer processors that supplement CPUs, often improving the execution of certain functions due to architectural design choices. We explore the approach of Services for Optimized Network Inference on Coprocessors (SONIC) and study the deployment of this as-a-service approach in large-scale data processing. In the studies, we take a data processing workflow of the CMS experiment and run the main workflow on CPUs, while offloading several machine learning (ML) inference tasks onto either remote or local coprocessors, specifically graphics processing units (GPUs). With experiments performed at Google Cloud, the Purdue Tier-2 computing center, and combinations of the two, we demonstrate the acceleration of these ML algorithms individually on coprocessors and the corresponding throughput improvement for the entire workflow. This approach can be easily generalized to different types of coprocessors and deployed on local CPUs without decreasing the throughput performance. We emphasize that the SONIC approach enables high coprocessor usage and enables the portability to run workflows on different types of coprocessors. 

A<sc>bstract</sc> A search for Higgs boson pair (HH) production in association with a vector boson V (W or Z boson) is presented. The search is based on proton-proton collision data at a center-of-mass energy of 13 TeV, collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 138 fb⁻¹. Both hadronic and leptonic decays of V bosons are used. The leptons considered are electrons, muons, and neutrinos. The HH production is searched for in the$$ \textrm{b}\overline{\textrm{b}}\textrm{b}\overline{\textrm{b}} $$ $b\overline{b}b\overline{b}$decay channel. An observed (expected) upper limit at 95% confidence level of VHH production cross section is set at 294 (124) times the standard model prediction. Constraints are also set on the modifiers of the Higgs boson trilinear self-coupling,k_λ, assumingk_2V= 1, and vice versa on the coupling of two Higgs bosons with two vector bosons,k_2V. The observed (expected) 95% confidence intervals of these coupling modifiers are−37.7 <k_λ< 37.2 (−30.1 <k_λ< 28.9) and−12.2 <k_2V< 13.5 (−7.2 <k_2V< 8.9), respectively. 

A<sc>bstract</sc> Diboson production in association with jets is studied in the fully leptonic final states, pp → (Z/γ^*)(Z/γ^*) + jets → 2ℓ2ℓ′ + jets, (ℓ,ℓ′ = e orμ) in proton-proton collisions at a center-of-mass energy of 13 TeV. The data sample corresponds to an integrated luminosity of 138 fb⁻¹collected with the CMS detector at the LHC. Differential distributions and normalized differential cross sections are measured as a function of jet multiplicity, transverse momentump_T, pseudorapidityη, invariant mass and ∆ηof the highest-p_Tand second-highest-p_Tjets, and as a function of invariant mass of the four-lepton system for events with various jet multiplicities. These differential cross sections are compared with theoretical predictions that mostly agree with the experimental data. However, in a few regions we observe discrepancies between the predicted and measured values. Further improvement of the predictions is required to describe the ZZ+jets production in the whole phase space. 

Abstract Using proton–proton collision data corresponding to an integrated luminosity of$$140\hbox { fb}^{-1}$$ $140{\text{fb}}^{-1}$collected by the CMS experiment at$$\sqrt{s}= 13\,\text {Te}\hspace{-.08em}\text {V} $$ $\sqrt{s}=13\text{Te}\text{V}$, the$${{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{\text {J}/\uppsi }} {{{\Xi }} ^{{-}}} {{\text {K}} ^{{+}}} $$ ${\Lambda }_{\text{b}}^0\to \text{J}/\psi {\Xi }^{-}{\text{K}}^{+}$decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the$${{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{{\uppsi }} ({2\textrm{S}})} {{\Lambda }} $$ ${\Lambda }_{\text{b}}^0\to \psi \left(2\text{S}\right)\Lambda$decay, is measured to be$$\mathcal {B}({{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{\text {J}/\uppsi }} {{{\Xi }} ^{{-}}} {{\text {K}} ^{{+}}} )/\mathcal {B}({{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{{\uppsi }} ({2\textrm{S}})} {{\Lambda }} ) = [3.38\pm 1.02\pm 0.61\pm 0.03]\%$$ $B({\Lambda }_{\text{b}}^0\to \text{J}/\psi {\Xi }^{-}{\text{K}}^{+})/B({\Lambda }_{\text{b}}^0\to \psi \left(2\text{S}\right)\Lambda )=[3.38\pm 1.02\pm 0.61\pm 0.03]\%$, where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in$$\mathcal {B}({{{\uppsi }} ({2\textrm{S}})} \rightarrow {{\text {J}/\uppsi }} {{{\uppi }} ^{{+}}} {{{\uppi }} ^{{-}}} )$$ $B(\psi \left(2\text{S}\right)\to \text{J}/\psi {\pi }^{+}{\pi }^{-})$and$$\mathcal {B}({{{\Xi }} ^{{-}}} \rightarrow {{\Lambda }} {{{\uppi }} ^{{-}}} )$$ $B({\Xi }^{-}\to \Lambda {\pi }^{-})$. 

A search for collective effects inside jets produced in proton-proton collisions is performed via correlation measurements of charged particles using the CMS detector at the CERN LHC. The analysis uses data collected at a center-of-mass energy of $\sqrt{s}=13\mathrm{TeV}$, corresponding to an integrated luminosity of $138{\mathrm{fb}}^{-1}$. Jets are reconstructed with the anti- $k_{\mathrm{T}}$algorithm with a distance parameter of 0.8 and are required to have transverse momentum greater than 550 GeV and pseudorapidity $\left|{\eta }^{\text{jet}}\right|<1.6$. Two-particle correlations among the charged particles within the jets are studied as functions of the particles’ azimuthal angle and pseudorapidity separations ( $\mathrm{\Delta }{\varphi }^{*}$and $\mathrm{\Delta }{\eta }^{*}$) in a jet coordinate basis, where particles’ ${\eta }^{*}$, ${\varphi }^{*}$are defined relative to the direction of the jet. The correlation functions are studied in classes of in-jet charged-particle multiplicity up to $N_{\mathrm{ch}}^{\mathrm{j}}\approx 100$. Fourier harmonics are extracted from long-range azimuthal correlation functions to characterize azimuthal anisotropy for $\left|\mathrm{\Delta }{\eta }^{*}\right|>2$. For low- $N_{\mathrm{ch}}^{\mathrm{j}}$jets, the long-range elliptic anisotropic harmonic, $v_2^{*}$, is observed to decrease with $N_{\mathrm{ch}}^{\mathrm{j}}$. This trend is well described by Monte Carlo event generators. However, a rising trend for $v_2^{*}$emerges at $N_{\mathrm{ch}}^{\mathrm{j}}\gtrsim 80$, hinting at a possible onset of collective behavior, which is not reproduced by the models tested. This observation yields new insights into the dynamics of jet evolution in the vacuum. © 2024 CERN, for the CMS Collaboration2024CERN 

A search is described for the production of a pair of bottom-type vectorlike quarks ( $B$VLQs) with mass greater than 1000 GeV. Each $B$VLQ decays into a $b$quark and a Higgs boson, a $b$quark and a $Z$boson, or a $t$quark and a $W$boson. This analysis considers both fully hadronic final states and those containing a charged lepton pair from a $Z$boson decay. The products of the $H\to bb$boson decay and of the hadronic $Z$or $W$boson decays can be resolved as two distinct jets or merged into a single jet, so the final states are classified by the number of reconstructed jets. The analysis uses data corresponding to an integrated luminosity of $138{\mathrm{fb}}^{-1}$collected in proton-proton collisions at $\sqrt{s}=13\mathrm{TeV}$with the CMS detector at the LHC from 2016 to 2018. No excess over the expected background is observed. Lower limits are set on the $B$VLQ mass at the 95% confidence level. These depend on the $B$VLQ branching fractions and are 1570 and 1540 GeV for 100% $B\to bH$and 100% $B\to bZ$, respectively. In most cases, the mass limits obtained exceed previous limits by at least 100 GeV. © 2024 CERN, for the CMS Collaboration2024CERN