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  1. ABSTRACT We present the photometry and spectroscopy of SN 2015an, a type II Supernova (SN) in IC 2367. The recombination phase of the SN lasts up to 120 d, with a decline rate of 1.24 mag/100d, higher than the typical SNe IIP. The SN exhibits bluer colours than most SNe II, indicating higher ejecta temperatures. The absolute V-band magnitude of SN 2015an at 50 d is −16.83 ± 0.04 mag, pretty typical for SNe II. However, the 56Ni mass yield, estimated from the tail V-band light curve to be 0.021 ± 0.010 M⊙, is comparatively low. The spectral properties of SN 2015an are atypical, with low H α expansion velocitymore »and presence of high-velocity component of H α at early phases. Moreover, the continuum exhibits excess blue flux up to 50 d, which is interpreted as a progenitor metallicity effect. The high-velocity feature indicates ejecta-circumstellar material interaction at early phases. The semi-analytical modelling of the bolometric light curve yields a total ejected mass of 12 M⊙, a pre-SN radius of 388 R⊙ and explosion energy of 1.8 foe.« less
  2. Abstract Cellular plasticity and transitional phenotypes add to complexities of cancer metastasis that can be initiated by single cell epithelial to mesenchymal transition (EMT) or cooperative cell migration (CCM). Our study identifies novel regulatory cross-talks between Tcf21 and Slug in mediating phenotypic and migration plasticity in high-grade serous ovarian adenocarcinoma (HGSC). Differential expression and subcellular localization associate Tcf21, Slug with epithelial, mesenchymal phenotypes, respectively; however, gene manipulation approaches identify their association with additional intermediate phenotypic states, implying the existence of a multistep epithelial-mesenchymal transition program. Live imaging further associated distinct migratory modalities with the Tcf21/Slug status of cell systems andmore »discerned proliferative/passive CCM, active CCM and EMT modes of migration. Tcf21–Slug balance identified across a phenotypic spectrum in HGSC cell lines, associated with microenvironment-induced transitions and the emergence of an epithelial phenotype following drug exposure. Phenotypic transitions and associated functionalities following drug exposure were affirmed to ensue from occupancy of Slug promoter E-box sequences by Tcf21. Our study effectively provides a framework for understanding the relevance of ovarian cancer plasticity as a function of two transcription factors.« less