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Saleem, M. (Ed.)NKX3.1’s downregulation is strongly associated with prostate cancer (PCa) initiation, progression, and CRPC development. Nevertheless, a clear disagreement exists between NKX3.1 protein and mRNA levels in PCa tissues, indicating that its regulation at a post-translational level plays a vital role. This study identified a strong negative relationship between NKX3.1 and LIMK2, which is critical in CRPC pathogenesis. We identified that NKX3.1 degradation by direct phosphorylation by LIMK2 is crucial for promoting oncogenicity in CRPC cells and in vivo. LIMK2 also downregulates NKX3.1 mRNA levels. In return, NKX3.1 promotes LIMK2’s ubiquitylation. Thus, the negative crosstalk between LIMK2-NKX3.1 regulates AR, ARv7, andmore »
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Free, publicly-accessible full text available July 1, 2022
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Future tactical communications involves high data rate best effort traffic working alongside real-time traffic for time-critical applications with hard deadlines. Unavailable bandwidth and/or untimely responses may lead to undesired or even catastrophic outcomes. Ethernet-based communication systems are one of the major tactical network standards due to the higher bandwidth, better utilization, and ability to handle heterogeneous traffic. However, Ethernet suffers from inconsistent performance for jitter, latency and bandwidth under heavy loads. The emerging Time-Triggered Ethernet (TTE) solutions promise deterministic Ethernet performance, fault-tolerant topologies and real-time guarantees for critical traffic. In this paper we study the TTE protocol and build amore »
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Free, publicly-accessible full text available March 1, 2023
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A bstract A search is presented for new particles produced at the LHC in proton-proton collisions at $$ \sqrt{s} $$ s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb − 1 , collected in 2017–2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with anmore »Free, publicly-accessible full text available November 1, 2022
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Abstract The production of $$\phi $$ ϕ mesons has been studied in pp collisions at LHC energies with the ALICE detector via the dimuon decay channel in the rapidity region $$2.5< y < 4$$ 2.5 < y < 4 . Measurements of the differential cross section $$\mathrm{d}^2\sigma /\mathrm{d}y \mathrm{d}p_{\mathrm {T}}$$ d 2 σ / d y d p T are presented as a function of the transverse momentum ( $$p_{\mathrm {T}}$$ p T ) at the center-of-mass energies $$\sqrt{s}=5.02$$ s = 5.02 , 8 and 13 TeV and compared with the ALICE results at midrapidity. The differential cross sections at $$\sqrt{s}=5.02$$more »Free, publicly-accessible full text available August 1, 2022
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Free, publicly-accessible full text available September 1, 2022
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Free, publicly-accessible full text available September 1, 2022